Osteoarthritis (OA), characterized by joint malfunction and chronic disability, is the most
common form of arthritis. Clinical and animal experiments reveal that age-related OA is …

Frailty is a common negative consequence of ageing. Sarcopenia, the syndrome of loss of
muscle mass, quality and strength, is more common in older adults and has been …

Major advances in preventing, delaying, or curing individual pathologies are responsible for
an increasingly long life span in the developed parts of our planet, and indeed reaching …

Obesity has become a major public health problem. Given the current increase in life
expectancy, the prevalence of obesity also raises steadily among older age groups. The …

After its discovery as a key controller of metabolic function, leptin has been later extensively
implicated in additional functions including important modulatory activities on the innate and …

Obesity is a chronic disease that represents one of the most serious global health burdens
associated to an excess of body fat resulting from an imbalance between energy intake and …

Leptin is a critical mediator of the immune response to changes in overall nutrition. Leptin is
produced by adipocytes in proportion to adipose tissue mass and is therefore increased in …

A large number of changes, distant from the site or sites of inflammation and involving many
organ systems, may accompany inflammation. In 1930 interest was focused on these …

There has been much effort recently to define the role of adipocytokines, which are soluble
mediators derived mainly from adipocytes (fat cells), in the interaction between adipose …

Nutritional deprivation suppresses immune function,,. The cloning of the obese gene and
identification of its protein product leptin has provided fundamental insight into the …