A large body of evidence generated in the last two and a half years addresses the roles of T
cells in SARS-CoV-2 infection and following vaccination. Infection or vaccination induces …

Predicting evolutionary outcomes is an important research goal in a diversity of contexts.
The focus of evolutionary forecasting is usually on adaptive processes, and efforts to …

Coronaviruses regularly cause outbreaks of zoonotic diseases characterized by severe
pneumonia. The new coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS …

Emerging variants of concern (VOC) raise obstacles in shaping vaccination strategies and
ending the pandemic. Vaccinated SARS-CoV-2 convalescence shapes the current immune …

The T-cell immune response is a major determinant of effective SARS-CoV-2 clearance.
Here, using the recently developed T-CoV bioinformatics pipeline (https://t-cov. hse. ru) we …

Memory T cells form from the adaptive immune response to historic infections or
vaccinations. Some memory T cells have the potential to recognise unrelated pathogens like …

Objective To investigate the changes of Spike protein-HLA binding affinity profiles between
the Wuhan strain and two dominant variants, the Delta and the Omicron strains, among the …

Patients with blood disorders who are immune suppressed are at increased risk for infection
with severe acute respiratory syndrome coronavirus 2. Sequelae of infection can include …

Next-generation T-cell-directed vaccines for COVID-19 focus on establishing lasting T-cell
immunity against current and emerging SARS-CoV-2 variants. Precise identification of …

Abstract The coronavirus disease 2019 (COVID-19) pandemic has caused human tragedy
through the global spread of the viral pathogen SARS-CoV-2. Although the underlying …