Neuroinflammation and neurogenesis in Alzheimer's disease and potential therapeutic approaches
In adult brain, new neurons are generated throughout adulthood in the subventricular zone
and the dentate gyrus; this process is commonly known as adult neurogenesis. The …
and the dentate gyrus; this process is commonly known as adult neurogenesis. The …
[HTML][HTML] Primary cilia and ciliary signaling pathways in aging and age-related brain disorders
Brain disorders are characterized by the progressive loss of structure and function of the
brain as a consequence of progressive degeneration and/or death of nerve cells. Aging is a …
brain as a consequence of progressive degeneration and/or death of nerve cells. Aging is a …
Genómica del síndrome de Down
S Díaz-Cuéllar, E Yokoyama-Rebollar… - Acta pediátrica de …, 2016 - scielo.org.mx
El síndrome de Down es la cromosomopatía más común del ser humano, con una
frecuencia de 1 en 650 recién nacidos vivos. Las manifestaciones clínicas son muy …
frecuencia de 1 en 650 recién nacidos vivos. Las manifestaciones clínicas son muy …
Exosome-like vesicles released from lipid-induced insulin-resistant muscles modulate gene expression and proliferation of beta recipient cells in mice
A Jalabert, G Vial, C Guay, OPB Wiklander, JZ Nordin… - Diabetologia, 2016 - Springer
Aims/hypothesis The crosstalk between skeletal muscle (SkM) and beta cells plays a role in
diabetes aetiology. In this study, we have investigated whether SkM-released exosome-like …
diabetes aetiology. In this study, we have investigated whether SkM-released exosome-like …
Mouse models of Down syndrome as a tool to unravel the causes of mental disabilities
N Rueda, J Flórez, C Martínez-Cué - Neural plasticity, 2012 - Wiley Online Library
Down syndrome (DS) is the most common genetic cause of mental disability. Based on the
homology of Hsa21 and the murine chromosomes Mmu16, Mmu17 and Mmu10, several …
homology of Hsa21 and the murine chromosomes Mmu16, Mmu17 and Mmu10, several …
The transcription factor FOXM1 (Forkhead box M1): proliferation-specific expression, transcription factor function, target genes, mouse models, and normal biological …
I Wierstra - Advances in cancer research, 2013 - Elsevier
Abstract FOXM1 (Forkhead box M1) is a typical proliferation-associated transcription factor,
which stimulates cell proliferation and exhibits a proliferation-specific expression pattern …
which stimulates cell proliferation and exhibits a proliferation-specific expression pattern …
Rodent models in Down syndrome research: impact and future opportunities
Down syndrome is caused by trisomy of chromosome 21. To date, a multiplicity of mouse
models with Down-syndrome-related features has been developed to understand this …
models with Down-syndrome-related features has been developed to understand this …
Timing of therapies for Down syndrome: the sooner, the better
Intellectual disability (ID) is the unavoidable hallmark of Down syndrome (DS), with a heavy
impact on public health. Accumulating evidence shows that DS is characterized by …
impact on public health. Accumulating evidence shows that DS is characterized by …
Down syndrome: searching for the genetic culprits
E Lana-Elola, SD Watson-Scales… - Disease models & …, 2011 - journals.biologists.com
Down syndrome (DS) is caused by trisomy of human chromosome 21 (Hsa21) and results in
a large number of phenotypes, including learning difficulties, cardiac defects, distinguishing …
a large number of phenotypes, including learning difficulties, cardiac defects, distinguishing …