Background and purpose White matter hyperintensities (WMHs) are associated with
cognitive deficits and worse clinical outcomes in dementia, but rare studies have been …

Background For over three decades, the concomitance of cortical neurodegeneration and
white matter hyperintensities (WMH) has sparked discussions about their coupled temporal …

Abstract Background White matter hyperintensities (WMHs) are often measured globally, but
spatial patterns of WMHs could underlie different risk factors and neuropathological and …

INTRODUCTION We investigated the interactive associations between amyloid and
hypertension on the entorhinal cortex (EC) tau and atrophy and the role of cerebral blood …

Individuals with Down syndrome (DS) are less likely to have hypertension than neurotypical
adults. However, whether blood pressure measures are associated with brain health and …

Importance: While the hallmark pathologies of amyloid-beta and tau in Alzheimer's disease
(AD) are well documented and even part of the definition, upstream neuroinflammation is …

Obstructive sleep apnea (OSA) is common in older adults and is associated with medial
temporal lobe (MTL) degeneration and memory decline in aging and Alzheimer's disease …

The Parkinson's Progression Markers Initiative (PPMI) delivers multiple modality MRI (M3RI)
and biomarker data for a comprehensive longitudinal study of Parkinson's Disease (PD) …

INTRODUCTION Cerebral small vessel disease (SVD) and amyloid beta (Aβ) pathology
frequently co‐exist. The impact of concurrent pathology on the pattern of hippocampal …

Extant research suggest aging-related losses of different dopaminergic markers, including
presynaptic dopamine transporters as well as post-synaptic DA receptors. Given the central …