Chemokines are proteins which induce chemotaxis, promote differentiation of immune cells,
and cause tissue extravasation. Given these properties, their role in anti-tumor immune …

IFN-γ, a soluble cytokine being produced by T lymphocytes, macrophages, mucosal
epithelial cells, or natural killer cells, is able to bind to the IFN-γ receptor (IFNγR) and in turn …

Advances in multiplexed in situ imaging are revealing important insights in spatial biology.
However, cell type identification remains a major challenge in imaging analysis, with most …

Chemokines govern leukocyte migration by attracting cells that express their cognate
ligands. Many cancer types show altered chemokine secretion profiles, favoring the …

More than 95% of the 20,000 to 25,000 transcribed human genes undergo alternative RNA
splicing, which increases the diversity of the proteome. Isoforms derived from the same gene …

Eliciting immune responses against primary tumours is hampered by their
immunosuppressive microenvironment and by the greater inaccessibility of deeper …

Purpose: Patients with head and neck squamous cell carcinoma (HNSCC) who actively
smoke during treatment have worse survival compared with never-smokers and former …

Chemokines are a group of low molecular weight peptides. Their major function is the
recruitment of leukocytes to inflammation sites, but they also play a key role in tumor growth …

Mixed lineage kinase domain-like protein (MLKL) emerged as executioner of necroptosis, a
RIPK3-dependent form of regulated necrosis. Cell death evasion is one of the hallmarks of …

Colorectal cancer (CRC) is one of the leading causes of cancer-related death worldwide.
Although most of the primary CRC can be removed by surgical resection, advanced tumors …