Communication between the central nervous and immune systems lies at the heart of the
neuroimmune axis. We trace here some of the major conceptual hurtles which were raised …

Fever is a common symptom of infectious and inflammatory disease. It is well-established
that prostaglandin E2 is the final mediator of fever, which by binding to its EP3 receptor …

Background Disruption of the blood-brain barrier (BBB) occurs in many diseases and is
often mediated by inflammatory and neuroimmune mechanisms. Inflammation is well …

During illnesses caused by infectious disease or other sources of inflammation, a suite of
brain-mediated responses called the sickness syndrome occurs, which includes fever …

Unipolar depression and diabetes mellitus each account for a significant proportion of the
global burden of disease. Epidemiological literature suggests a bi-directional relationship …

The blood–brain barrier (BBB) was first noted for its ability to prevent the unregulated
exchange of substances between the blood and the central nervous system (CNS). Over …

Acetaminophen (INN, paracetamol) possesses highly selective analgesic and antipyretic
effects that result from its inhibitory actions on the synthesis of prostaglandins (PGs). PGs are …

Systemic inflammation-associated syndromes (eg, sepsis and septic shock) often have high
mortality and remain a challenge in emergency medicine. Systemic inflammation is usually …

Peripheral inflammation involves an increase in cyclooxygenase-2 (COX-2)-mediated
prostaglandin (PG) synthesis in the central nervous system (CNS), which contributes to …

We studied the febrile response in mice deficient in microsomal prostaglandin E synthase-1
(mPGES-1), an inducible terminal isomerase expressed in cytokine-sensitive brain …