Background Multiple sclerosis (MS) is an autoimmune, demyelinating disease of the central
nervous system. The treatment of MS has always been a focus of neurological research. To …

The pathogenesis of multiple sclerosis (MS) involves complex interactions between genetic
susceptibility and environmental triggers. Clinical observations suggest that the study of sex …

Background A female/male (F/M) ratio increase over time in multiple sclerosis (MS) patients
was demonstrated in many countries around the world. So far, a direct comparison of sex …

Multiple sclerosis (MS) is the most common acquired inflammatory demyelinating disorder of
the central nervous system (CNS). Not unlike many inflammatory diseases with a presumed …

Multiple sclerosis (MS) is more prevalent in females than males, and this female
predominance is increasing as time goes by. Additionally, gender appears to play critical …

This review summarizes and integrates research on vitamin D and CD4+ T-lymphocyte
biology to develop new mechanistic insights into the molecular etiology of autoimmune …

Background: Multiple sclerosis (MS) is thought to be caused by T-cell mediated autoimmune
dysfunction. Risk of developing MS is influenced by environmental and genetic factors …

Neurosteroids are steroid hormones synthesised de novo in the brain and peripheral
nervous tissues. In contrast to adrenal steroid hormones that act on intracellular nuclear …

In recent decades, pregnancy-related issues in multiple sclerosis (MS) have received
growing interest. MS is more frequent in women than in men and typically starts during child …

Growing evidence supports significant involvement of immune dysfunction in the etiology of
neurodegenerative diseases, several of which also display prominent sex differences across …