The acute respiratory distress syndrome (ARDS) is a common cause of respiratory failure in
critically ill patients and is defined by the acute onset of noncardiogenic pulmonary oedema …

The Na+-K+-ATPase, or sodium pump, is the membrane-bound enzyme that maintains the
Na+ and K+ gradients across the plasma membrane of animal cells. Because of its …

Because experimental studies have shown that intact alveolar epithelial fluid transport
function is critical for resolution of pulmonary edema and acute lung injury, we measured net …

The discovery of mechanisms that regulate salt and water transport by the alveolar and
distal airway epithelium of the lung has generated new insights into the regulation of lung …

▪ Abstract The discovery that nitric oxide (NO) is produced by neurons and regulates
synaptic activity has challenged the definition of a neurotransmitter. NO is not stored in …

Sodium absorption by an amiloride-sensitive channel is the main driving force of lung liquid
clearance at birth and lung edema clearance in adulthood. In this study, we tested whether …

▪ Abstract At birth, fetal distal lung epithelial (FDLE) cells switch from active chloride
secretion to active sodium (Na+) reabsorption. Sodium ions Senter the FDLE and alveolar …

Falciparum malaria is a complex disease with no simple explanation, affecting organs where
the parasite is rare as well as those organs where it is more common. We continue to argue …

Amiloride-sensitive epithelial sodium channels (ENaC) play an important role in lung
sodium transport. Sodium transport is closely regulated to maintain an appropriate fluid layer …

▪ Abstract The developing distal lung epithelium displays an evolving liquid transport
phenotype, reflecting a changing and dynamic balance between Cl− ion secretion and Na+ …