S Manzoor, N Hoda - European journal of medicinal chemistry, 2020 - Elsevier
Monoamine oxidases (MAO-A and MAO-B) are mammalian flavoenzyme, which catalyze the oxidative deamination of several neurotransmitters like norepinephrine, dopamine, tyramine …
Y Li, L Zhang, Z Liu - Journal of cheminformatics, 2018 - Springer
Recently, deep generative models have revealed itself as a promising way of performing de novo molecule design. However, previous research has focused mainly on generating …
Oxygen heterocycles are the second most common type of heterocycles that appear as structural components of US Food and Drug Administration (FDA) approved …
V Palani, MA Perea, R Sarpong - Chemical reviews, 2021 - ACS Publications
Methods to functionalize arenes and heteroarenes in a site-selective manner are highly sought after for rapidly constructing value-added molecules of medicinal, agrochemical, and …
S Pan, M Song, L Zuo, X Geng… - The Journal of Organic …, 2023 - ACS Publications
Herein, we present a practical strategy for the direct construction of structurally diverse trifluoromethyl carbinol-containing compounds, especially CF3-substituted tertiary alcohol …
M Dhameja, P Gupta - European journal of medicinal chemistry, 2019 - Elsevier
Abstract α-Glucosidase enzyme inhibition is an effective therapeutic decorum in the treatment of type 2 diabetes mellitus. Since 1990, three α-glucosidase inhibitors are known …
Accomplished herein is a rearrangement strategy for the highly efficient assembly of synthetically cumbersome while medicinally significant 2-amino-3-formyl chromones via …
B Tang, F He, D Liu, F He, T Wu, M Fang, Z Niu, Z Wu… - Biomolecules, 2022 - mdpi.com
The drug repurposing of known approved drugs (eg, lopinavir/ritonavir) has failed to treat SARS-CoV-2-infected patients. Therefore, it is important to generate new chemical entities …
CS Tan, NM Isa, I Ismail, Z Zainal - Frontiers in plant science, 2019 - frontiersin.org
Agarwood is a resinous part of the non-timber Aquilaria tree, which is a highly valuable product for medicine and fragrance purposes. To protect the endangered Aquilaria species …