TRP (transient receptor potential) ion channel family: Structures, biological functions and therapeutic interventions for diseases
Transient receptor potential (TRP) channels are sensors for a variety of cellular and
environmental signals. Mammals express a total of 28 different TRP channel proteins, which …
environmental signals. Mammals express a total of 28 different TRP channel proteins, which …
TRPV4: molecular conductor of a diverse orchestra
Transient receptor potential vanilloid type 4 (TRPV4) is a calcium-permeable nonselective
cation channel, originally described in 2000 by research teams led by Schultz (Nat Cell Biol …
cation channel, originally described in 2000 by research teams led by Schultz (Nat Cell Biol …
A TRPV4-dependent neuroimmune axis in the spinal cord promotes neuropathic pain
Microglia, resident macrophages of the CNS, are essential to brain development,
homeostasis, and disease. Microglial activation and proliferation are hallmarks of many CNS …
homeostasis, and disease. Microglial activation and proliferation are hallmarks of many CNS …
Regulation of pain and itch by TRP channels
Nociception is an important physiological process that detects harmful signals and results in
pain perception. In this review, we discuss important experimental evidence involving some …
pain perception. In this review, we discuss important experimental evidence involving some …
Transient receptor potential channels as drug targets: from the science of basic research to the art of medicine
The large Trp gene family encodes transient receptor potential (TRP) proteins that form
novel cation-selective ion channels. In mammals, 28 Trp channel genes have been …
novel cation-selective ion channels. In mammals, 28 Trp channel genes have been …
Histamine receptor H1–mediated sensitization of TRPV1 mediates visceral hypersensitivity and symptoms in patients with irritable bowel syndrome
MM Wouters, D Balemans, S Van Wanrooy, J Dooley… - Gastroenterology, 2016 - Elsevier
Background & Aims Histamine sensitizes the nociceptor transient reporter potential channel
V1 (TRPV1) and has been shown to contribute to visceral hypersensitivity in animals. We …
V1 (TRPV1) and has been shown to contribute to visceral hypersensitivity in animals. We …
Involvement of neural transient receptor potential channels in peripheral inflammation
HA Silverman, A Chen, NL Kravatz… - Frontiers in …, 2020 - frontiersin.org
Transient receptor potential (TRP) channels are a superfamily of non-selective cation
channels that act as polymodal sensors in many tissues throughout mammalian organisms …
channels that act as polymodal sensors in many tissues throughout mammalian organisms …
Visceral pain
L Grundy, A Erickson, SM Brierley - Annual review of physiology, 2019 - annualreviews.org
Most of us live blissfully unaware of the orchestrated function that our internal organs
conduct. When this peace is interrupted, it is often by routine sensations of hunger and urge …
conduct. When this peace is interrupted, it is often by routine sensations of hunger and urge …
Enteric glia modulate macrophage phenotype and visceral sensitivity following inflammation
V Grubišić, JL McClain, DE Fried, I Grants… - Cell reports, 2020 - cell.com
Mechanisms resulting in abdominal pain include altered neuro-immune interactions in the
gastrointestinal tract, but the signaling processes that link immune activation with visceral …
gastrointestinal tract, but the signaling processes that link immune activation with visceral …
Transient receptor potential (TRP) channels: a clinical perspective
Y Kaneko, A Szallasi - British journal of pharmacology, 2014 - Wiley Online Library
Transient receptor potential (TRP) channels are important mediators of sensory signals with
marked effects on cellular functions and signalling pathways. Indeed, mutations in genes …
marked effects on cellular functions and signalling pathways. Indeed, mutations in genes …