Ischemic heart disease is one of the main causes of morbidity and mortality in the world. In
adult mammalian hearts, most cardiomyocytes are terminally differentiated and have …

Thanks to their abilities to modulate the expression of virtually any genes, RNA therapeutics
have attracted considerable research efforts. Among the strategies focusing on nucleic acid …

Doxorubicin (DOX) could trigger congestive heart failure, which largely limited the clinical
use of DOX. microRNAs (miRNAs) were closely involved in the pathogenesis of DOX …

Cancer is one of the leading causes of morbidity and mortality worldwide. Significant
improvements in the modern era of anticancer therapeutic strategies have increased the …

In the past years, microRNAs (miRNAs) have emerged as important biomarkers and
essential regulators of many pathophysiological processes. Several studies have focused …

Mitochondria are the key organelles that supply cellular energy. As the most active organ in
the body, the energy required to maintain the mechanical function of the heart requires a …

Abstract Background Aloe-emodin (AE), a natural anthraquinone extract from traditional
Chinese medicinal plants, has been certified to protect against acute myocardial ischemia …

Among the thioredoxin superfamily of proteins, the observation that numerous glutaredoxins
bind iron-sulphur (Fe/S) clusters is one of the more recent and major developments …

Globally, ischemic stroke causes millions of deaths per year. The outcomes of ischemic
stroke are largely determined by the amount of ischemia-related and reperfusion-related …

Dilated cardiomyopathy (DCM) is a clinical diagnosis characterized by left ventricular or
biventricular dilation and systolic dysfunction. In most cases, DCM is progressive, leading to …