The uptake of calcium into and extrusion of calcium from the mitochondrial matrix is a
fundamental biological process that has critical effects on cellular metabolism, signaling …

Abstract Changes in cytosolic free Ca 2+ concentration ([Ca 2+] c) play a crucial role in the
control of insulin secretion from the electrically excitable pancreatic β-cell. Secretion is …

Physiologic Ca 2+ entry via the Mitochondrial Calcium Uniporter (MCU) participates in
energetic adaption to workload but may also contribute to cell death during …

Mitochondria from every tissue are quite similar in their capability to accumulate Ca 2+ in a
process that depends on the electrical potential across the inner membrane; it is catalyzed …

Mitochondria not only provide cells with energy, but are central to Ca2+ signaling. Powered
by the mitochondrial membrane potential, Ca2+ enters the mitochondria and is released into …

The role of mitochondria in cell signaling is becoming increasingly apparent, to an extent
that the signaling role of mitochondria appears to have stolen the spotlight from their primary …

Mitochondrial Ca2+ is known to change dynamically, regulating mitochondrial as well as
cellular functions such as energy metabolism and apoptosis. The NCLX gene encodes the …

Mitochondria mediate dual metabolic and Ca2+ shuttling activities. While the former is
required for Ca2+ signalling linked to insulin secretion, the role of the latter in β cell function …

The mitochondrial Na+-Ca2+ exchanger, NCLX, was reported to supply Ca2+ to
sarcoplasmic reticulum (SR)/endoplasmic reticulum, thereby modulating various cellular …

Mitochondria are emerging as a major hub for cellular Ca2+-signaling, though their
contribution to Ca2+-driven growth-and survival-promoting events in cancer is poorly …