Pathophysiology of chronic graft-versus-host disease and therapeutic targets

R Zeiser, BR Blazar - New England Journal of Medicine, 2017 - Mass Medical Soc
Chronic GVHD, an autoimmune disease that follows allogeneic hematopoietic-cell
transplantation, is characterized by infections and debilitating tissue injury leading to …

Classification systems for chronic graft-versus-host disease

SJ Lee - Blood, The Journal of the American Society of …, 2017 - ashpublications.org
Chronic graft versus host disease (GVHD) is a major cause of morbidity and mortality after
allogeneic hematopoietic cell transplantation. Clinically, chronic GVHD is a pleiotropic …

[HTML][HTML] Ruxolitinib for glucocorticoid-refractory chronic graft-versus-host disease

R Zeiser, N Polverelli, R Ram, SK Hashmi… - … England Journal of …, 2021 - Mass Medical Soc
Background Chronic graft-versus-host disease (GVHD), a major complication of allogeneic
stem-cell transplantation, becomes glucocorticoid-refractory or glucocorticoid-dependent in …

EBMT− NIH− CIBMTR Task Force position statement on standardized terminology & guidance for graft-versus-host disease assessment

HM Schoemans, SJ Lee, JL Ferrara, D Wolff… - Bone marrow …, 2018 - nature.com
Several international recommendations address the assessment of graft-versus-host
disease (GvHD) after hematopoietic cell transplantation (HCT). This position statement by …

Chronic graft-versus-host disease: biological insights from preclinical and clinical studies

KPA MacDonald, GR Hill… - Blood, The Journal of the …, 2017 - ashpublications.org
With the increasing use of mismatched, unrelated, and granulocyte colony-stimulating factor–
mobilized peripheral blood stem cell donor grafts and successful treatment of older …

How I treat refractory chronic graft-versus-host disease

S Sarantopoulos, AR Cardones… - Blood, The Journal of …, 2019 - ashpublications.org
Abstract Approximately 35% to 50% of patients otherwise cured of hematologic
malignancies after allogeneic hematopoietic stem cell transplantation will develop the …

How ibrutinib, a B-cell malignancy drug, became an FDA-approved second-line therapy for steroid-resistant chronic GVHD

SM Jaglowski, BR Blazar - Blood advances, 2018 - ashpublications.org
Allogeneic hematopoietic stem cell transplantation (allo-SCT) is potentially curative for a
number of hematologic conditions, both malignant and nonmalignant. However, its success …

Biomarker panel for chronic graft-versus-host disease

J Yu, BE Storer, K Kushekhar, M Abu Zaid… - Journal of Clinical …, 2016 - ascopubs.org
Purpose To identify diagnostic and prognostic markers of chronic graft-versus-host disease
(cGVHD), the major cause of morbidity and mortality after allogeneic hematopoietic cell …

[HTML][HTML] National Institutes of Health consensus development project on criteria for clinical trials in chronic graft-versus-host disease: III. The 2020 treatment of chronic …

Z DeFilipp, DR Couriel, A Lazaryan, VR Bhatt… - … and cellular therapy, 2021 - Elsevier
Positive results from recent clinical trials have significantly expanded current therapeutic
options for patients with chronic graft-versus-host disease (GVHD). However, new insights …

Updates in chronic graft‐versus‐host disease management

F Malard, M Mohty - American journal of hematology, 2023 - Wiley Online Library
Chronic graft‐versus‐host disease (cGvHD) remains the most important long‐term
complication of allogeneic hematopoietic cell transplantation (allo‐HCT), but the field has …