Viral hepatitis: etiology, epidemiology, transmission, diagnostics, treatment, and prevention

S Lanini, A Ustianowski, R Pisapia, A Zumla… - Infectious Disease …, 2019 - id.theclinics.com
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Hepatitis E: an underestimated emerging threat

GW Webb, HR Dalton - Therapeutic advances in infectious …, 2019 - journals.sagepub.com
Hepatitis E virus (HEV) is the most common cause of viral hepatitis in the world. It is
estimated that millions of people are infected every year, resulting in tens of thousands of …

Hepatitis E virus ORF3 is a functional ion channel required for release of infectious particles

Q Ding, B Heller, JMV Capuccino… - Proceedings of the …, 2017 - National Acad Sciences
Hepatitis E virus (HEV) is the leading cause of enterically transmitted viral hepatitis globally.
Of HEV's three ORFs, the function of ORF3 has remained elusive. Here, we demonstrate that …

Public health risks associated with hepatitis E virus (HEV) as a food‐borne pathogen

EFSA Panel on Biological Hazards (BIOHAZ)… - Efsa …, 2017 - Wiley Online Library
Hepatitis E virus (HEV) is an important infection in humans in EU/EEA countries, and over
the last 10 years more than 21,000 acute clinical cases with 28 fatalities have been notified …

Origin, antigenicity, and function of a secreted form of ORF2 in hepatitis E virus infection

X Yin, D Ying, S Lhomme, Z Tang… - Proceedings of the …, 2018 - National Acad Sciences
The enterically transmitted hepatitis E virus (HEV) adopts a unique strategy to exit cells by
cloaking its capsid (encoded by the viral ORF2 gene) and circulating in the blood as “quasi …

Genotype specific pathogenicity of hepatitis E virus at the human maternal-fetal interface

J Gouilly, Q Chen, J Siewiera, G Cartron, C Levy… - Nature …, 2018 - nature.com
Hepatitis E virus (HEV) infection, particularly HEV genotype 1 (HEV-1), can result in
fulminant hepatic failure and severe placental diseases, but mechanisms underlying …

Virus–host cell interplay during hepatitis E virus infection

MH Wißing, Y Brüggemann, E Steinmann, D Todt - Trends in microbiology, 2021 - cell.com
The molecular interplay between cellular host factors and viral proteins is a continuous
process throughout the viral life cycle determining virus host range and pathogenesis. The …

Hepatitis E virus infections in Europe

J Izopet, P Tremeaux, O Marion, M Migueres… - Journal of Clinical …, 2019 - Elsevier
Hepatitis E virus (HEV) is the most common cause of acute viral hepatitis worldwide. The
systematic use of improved tools for diagnosing and genotyping has completely changed …

Stem cell-derived polarized hepatocytes

VL Dao Thi, X Wu, RL Belote, U Andreo… - Nature …, 2020 - nature.com
Human stem cell-derived hepatocyte-like cells (HLCs) offer an attractive platform to study
liver biology. Despite their numerous advantages, HLCs lack critical in vivo characteristics …

Robust hepatitis E virus infection and transcriptional response in human hepatocytes

D Todt, M Friesland, N Moeller… - Proceedings of the …, 2020 - National Acad Sciences
Hepatitis E virus (HEV) is the causative agent of hepatitis E in humans and the leading
cause for acute viral hepatitis worldwide. The virus is classified as a member of the genus …