Colorectal cancer (CRC) is a predominant life‐threatening cancer, with liver and peritoneal
metastases as the primary causes of death. Intestinal inflammation, a known CRC risk factor …

Simple Summary Tumor growth in solid cancers requires adequate nutrient and oxygen
supply, provided by blood vessels created by angiogenesis. Numerous studies have …

The emergence of novel immunomodulatory cancer therapies over the last decade, above
all immune checkpoint blockade, has significantly advanced tumor treatment. For colorectal …

Innate lymphoid cells (ILCs) are tissue-resident lymphocytes differing from conventional T
lymphocytes in having no antigen-specific receptors. ILCs include natural killer (NK) cells …

Group 2 innate lymphoid cells (ILC2s) play a critical role in protection against helminths and
in diverse inflammatory diseases by responding to soluble factors such as the alarmin IL-33 …

According to the Geroscience concept that organismal aging and age-associated diseases
share the same basic molecular mechanisms, the identification of biomarkers of age that can …

Abstract IL-33, an IL-1 family member, is expressed by many cell types and can regulate
gene transcription. IL-33 is released upon cell necrosis and the precursor form is …

Tumor epithelial cells develop within a microenvironment consisting of extracellular matrix,
growth factors, and cytokines produced by nonepithelial stromal cells. In response to …

Mast cells (MCs) are multifaceted innate immune cells often present in the tumor
microenvironment (TME). Several recent findings support their contribution to the transition …

Liver metastasis is the major cause of death from colorectal cancer (CRC). Understanding its
mechanisms is necessary for timely diagnosis and development of effective therapies …