Chalcone: a privileged structure in medicinal chemistry

C Zhuang, W Zhang, C Sheng, W Zhang, C Xing… - Chemical …, 2017 - ACS Publications
Privileged structures have been widely used as an effective template in medicinal chemistry
for drug discovery. Chalcone is a common simple scaffold found in many naturally occurring …

Catalytic enantioselective desymmetrization reactions to all-carbon quaternary stereocenters

XP Zeng, ZY Cao, YH Wang, F Zhou, J Zhou - Chemical Reviews, 2016 - ACS Publications
This Review summarizes the advances in the construction of all-carbon quaternary
stereocenters via catalytic enantioselective desymmetrization of prochiral and meso …

Asymmetric Cycloaddition and Cyclization Reactions Catalyzed by Chiral N,N′-Dioxide–Metal Complexes

X Liu, H Zheng, Y Xia, L Lin, X Feng - Accounts of chemical …, 2017 - ACS Publications
Conspectus Catalytic asymmetric cycloadditions and cascade cyclizations are a major focus
for the enantioselective construction of chiral carbo-and heterocycles. A number of chiral …

Combinations of aminocatalysts and metal catalysts: a powerful cooperative approach in selective organic synthesis

S Afewerki, A Cordova - Chemical reviews, 2016 - ACS Publications
The cooperation and interplay between organic and metal catalyst systems is of utmost
importance in nature and chemical synthesis. Here innovative and selective cooperative …

Catalytic C–C bond-forming multi-component cascade or domino reactions: Pushing the boundaries of complexity in asymmetric organocatalysis

CMR Volla, I Atodiresei, M Rueping - Chemical Reviews, 2014 - ACS Publications
The construction of carbon− carbon bonds, along with the creation of stereogenic carbon
centers, continues to be an appealing and demanding area of research, and processes in …

Catalytic enantioselective construction of spiro quaternary carbon stereocenters

PW Xu, JS Yu, C Chen, ZY Cao, F Zhou, J Zhou - ACS Catalysis, 2019 - ACS Publications
The catalytic enantioselective assembly of spirocyclic molecules featuring a spiro quaternary
carbon stereocenter is currently of great interest because such privileged 3D structures are …

Bifunctional amine‐squaramides: powerful hydrogen‐bonding organocatalysts for asymmetric domino/cascade reactions

P Chauhan, S Mahajan, U Kaya… - … Synthesis & Catalysis, 2015 - Wiley Online Library
Organocatalytic domino/cascade reactions provide a convenient method for the construction
of complex molecular structures bearing multiple stereocenters in a highly stereoselective …

Chirality in rotaxanes and catenanes

EMG Jamieson, F Modicom, SM Goldup - Chemical Society Reviews, 2018 - pubs.rsc.org
Although chiral mechanically interlocked molecules (MIMs) have been synthesised and
studied, enantiopure examples are relatively under-represented in the pantheon of reported …

Recent advances in Pd-catalyzed asymmetric cyclization reactions

B Xu, Q Wang, C Fang, ZM Zhang… - Chemical Society Reviews, 2024 - pubs.rsc.org
Over the past few decades, there have been major developments in transition metal-
catalyzed asymmetric cyclization reactions, enabling the convenient access to a wide …

Formal [4+ 1] annulation reactions in the synthesis of carbocyclic and heterocyclic systems

JR Chen, XQ Hu, LQ Lu, WJ Xiao - Chemical reviews, 2015 - ACS Publications
The development of new strategies and chemical reactions continues to be a major focus of
research efforts in the modern synthetic organic community. 1 Of the various types of …