Epilepsy is among the most dynamic disorders in neurology. A canonical view holds that
seizures, the characteristic sign of epilepsy, occur at random, but, for centuries, humans …

People with epilepsy frequently have cognitive impairment. The majority of cognitive
problems is influenced by a variety of interlinked factors, including the early onset of …

It is typically assumed that large networks of neurons exhibit a large repertoire of nonlinear
behaviours. Here we challenge this assumption by leveraging mathematical models derived …

With advances in healthcare and an ageing population, the number of older adults with
epilepsy is set to rise substantially across the world. In developed countries the highest …

Decades of rodent research have established the role of hippocampal sharp wave ripples
(SPW-Rs) in consolidating and guiding experience. More recently, intracranial recordings in …

Objective While many studies suggest that patients with Alzheimer's disease have a higher
chance for developing epileptic seizures, only a few studies are available examining …

Temporal lobe epilepsy represents a major cause of drug-resistant epilepsy. Cognitive
impairment is a frequent comorbidity, but the mechanisms are not fully elucidated. We …

People with Alzheimer's disease (AD) have significantly higher rates of subclinical and overt
epileptiform activity. In animal models, oligomeric Aβ amyloid is able to induce neuronal …

Accurate identification of seizure activity, both clinical and subclinical, has important
implications in the management of epilepsy. Accurate recognition of seizure activity is …

The location of interictal spikes is used to aid surgical planning in patients with medically
refractory epilepsy; however, their spatial and temporal dynamics are poorly understood. In …