Silencing disease genes in the laboratory and the clinic
Synthetic nucleic acids are commonly used laboratory tools for modulating gene expression
and have the potential to be widely used in the clinic. Progress towards nucleic acid drugs …
and have the potential to be widely used in the clinic. Progress towards nucleic acid drugs …
[图书][B] Therapeutic oligonucleotides
J Goodchild - 2011 - Springer
A brief historical introduction describes early attempts to silence specific genes using the
antisense oligonucleotides that flourished in the 1980s. Early aspirations for therapeutic …
antisense oligonucleotides that flourished in the 1980s. Early aspirations for therapeutic …
Bcl-6 mediates the germinal center B cell phenotype and lymphomagenesis through transcriptional repression of the DNA-damage sensor ATR
Antibody specificity and diversity is generated in B cells during germinal center maturation
through clonal expansion while they undergo class-switch recombination and somatic …
through clonal expansion while they undergo class-switch recombination and somatic …
2′-Deoxy-2′-fluoro-β- d -arabinonucleic acid (2′F-ANA) modified oligonucleotides (ON) effect highly efficient, and persistent, gene silencing
A Kalota, L Karabon, CR Swider… - Nucleic acids …, 2006 - academic.oup.com
To be effective in vivo, antisense oligonucleotides (AS ON) should be nuclease resistant,
form stable ON/RNA duplexes and support ribonuclease H mediated heteroduplex …
form stable ON/RNA duplexes and support ribonuclease H mediated heteroduplex …
[HTML][HTML] Gene silencing by siRNAs and antisense oligonucleotides in the laboratory and the clinic
Synthetic nucleic acids are commonly used laboratory tools for modulating gene expression
and have the potential to be widely used in the clinic. Progress towards nucleic acid drugs …
and have the potential to be widely used in the clinic. Progress towards nucleic acid drugs …
Regulating gene expression in human leukemia cells using light-activated oligodeoxynucleotides
XJ Tang, J Swaminathan, AM Gewirtz… - Nucleic acids …, 2008 - academic.oup.com
Light-activated antisense oligodeoxynucleotides (asODNs) were developed to control the
degradation of target mRNA in living cells by RNase H. A 20-mer asODN previously shown …
degradation of target mRNA in living cells by RNase H. A 20-mer asODN previously shown …
RNA based gene therapy for dominantly inherited diseases
R Pelletier, SOP Caron, J Puymirat - Current gene therapy, 2006 - ingentaconnect.com
There are numerous examples in the literature of gene therapy applications for recessive
disorders. There are precious few instances, however, of studies conducted to treat …
disorders. There are precious few instances, however, of studies conducted to treat …
Progress in the development of nucleic acid therapeutics
A Kalota, VR Dondeti, AM Gewirtz - RNA Towards Medicine, 2006 - Springer
Abnormal gene expression is a hallmark of many diseases. Gene-specific down-regulation
of aberrant genes could be useful therapeutically and potentially less toxic than …
of aberrant genes could be useful therapeutically and potentially less toxic than …
Rapid selection of accessible and cleavable sites in RNA by Escherichia coli RNase P and random external guide sequences
EW Lundblad, G Xiao, J Ko… - Proceedings of the …, 2008 - National Acad Sciences
A method of inhibiting the expression of particular genes by using external guide sequences
(EGSs) has been improved in its rapidity and specificity. Random EGSs that have 14-nt …
(EGSs) has been improved in its rapidity and specificity. Random EGSs that have 14-nt …
A Fluorescent Tile DNA Diagnocode System for In Situ Rapid and Selective Diagnosis of Cytosolic RNA Cancer Markers
Accurate cancer diagnosis often requires extraction and purification of genetic materials
from cells and sophisticated instrumentations that follow. Otherwise in order to directly treat …
from cells and sophisticated instrumentations that follow. Otherwise in order to directly treat …