Unraveling genetic mysteries: A comprehensive review of GWAS and DNA insights in animal and plant pathosystems

N Liu, M Guan, B Ma, H Chu, G Tian, Y Zhang… - International Journal of …, 2024 - Elsevier
DNA serves as the carrier of genetic information, with sequence variations playing a pivotal
role in defining hereditary traits. Genome-Wide Association Studies (GWAS) facilitate the …

Genome-wide association study between SARS-CoV-2 single nucleotide polymorphisms and virus copies during infections

K Li, C Chaguza, J Stamp, YT Chew… - PLOS Computational …, 2024 - journals.plos.org
Significant variations have been observed in viral copies generated during SARS-CoV-2
infections. However, the factors that impact viral copies and infection dynamics are not fully …

Intergenomic signatures of coevolution between Tasmanian devils and an infectious cancer

DG Gallinson, CP Kozakiewicz… - Proceedings of the …, 2024 - National Acad Sciences
Coevolution is common and frequently governs host–pathogen interaction outcomes.
Phenotypes underlying these interactions often manifest as the combined products of the …

Deep learning identified genetic variants for COVID‐19‐related mortality among 28,097 affected cases in UK Biobank

Z Liu, W Dai, S Wang, Y Yao, H Zhang - Genetic epidemiology, 2023 - Wiley Online Library
Abstract Analysis of host genetic components provides insights into the susceptibility and
response to viral infection such as severe acute respiratory syndrome coronavirus 2 (SARS …

Temporal trends of severity and outcomes of critically ill patients with COVID-19 after the emergence of variants of concern: A comparison of two waves

DHM Freitas, ELV Costa, NA Zimmermann, LSO Gois… - Plos one, 2024 - journals.plos.org
Background The emergence of SARS-CoV-2 variants led to subsequent waves of COVID-19
worldwide. In many countries, the second wave of COVID-19 was marked by record deaths …

Predictive model for severe COVID-19 using SARS-CoV-2 whole-genome sequencing and electronic health record data, March 2020-May 2021

L Zhu, JW Marsh, MP Griffith, K Collins, V Srinivasa… - PloS one, 2022 - journals.plos.org
Objective We used SARS-CoV-2 whole-genome sequencing (WGS) and electronic health
record (EHR) data to investigate the associations between viral genomes and clinical …

Effects of Epitranscriptomic RNA Modifications on the Catalytic Activity of the SARS‐CoV‐2 Replication Complex

A Apostle, Y Yin, K Chillar, AMDN Eriyagama… - …, 2023 - Wiley Online Library
SARS‐CoV‐2 causes individualized symptoms. Many reasons have been given. We
propose that an individual's epitranscriptomic system could be responsible as well. The viral …

[HTML][HTML] Data-driven platform for identifying variants of interest in COVID-19 virus

P Ramarao-Milne, Y Jain, LMF Sng, B Hosking… - Computational and …, 2022 - Elsevier
New SARS-CoV-2 variants emerge as part of the virus' adaptation to the human host. The
Health Organizations are monitoring newly emerging variants with suspected impact on …

El efecto de la composición étnico-racial de la población en la mortalidad por COVID-19: un enfoque ecológico espacial de las inequidades en salud en Brasil

JMD Cajazeiro, AM Cardoso… - Ciência & Saúde …, 2024 - SciELO Public Health
La pandemia de COVID-19 ha afectado de forma desigual a regiones, países y diferentes
grupos raciales/étnicos. Los factores socioambientales han sido asociados a una peor …

Fast computation of the eigensystem of genomic similarity matrices

G Hahn, SM Lutz, J Hecker, D Prokopenko, MH Cho… - BMC …, 2024 - Springer
The computation of a similarity measure for genomic data is a standard tool in computational
genetics. The principal components of such matrices are routinely used to correct for biases …