Hyperpolarized Xenon-129 Chemical Exchange Saturation Transfer (HyperCEST) Molecular Imaging: Achievements and Future Challenges

V Batarchuk, Y Shepelytskyi, V Grynko… - International Journal of …, 2024 - mdpi.com
Molecular magnetic resonance imaging (MRI) is an emerging field that is set to revolutionize
our perspective of disease diagnosis, treatment efficacy monitoring, and precision medicine …

Enolase inhibitors as therapeutic leads for Naegleria fowleri infection

JE Milanes, VC Yan, CD Pham, F Muller… - PLoS …, 2024 - journals.plos.org
Infections with the pathogenic free-living amoebae Naegleria fowleri can lead to life-
threatening illnesses including catastrophic primary amoebic meningoencephalitis (PAM) …

Prodrugs of a 1-Hydroxy-2-oxopiperidin-3-yl Phosphonate Enolase Inhibitor for the Treatment of ENO1-Deleted Cancers

VC Yan, CD Pham, ES Ballato, KL Yang… - Journal of Medicinal …, 2022 - ACS Publications
Cancers harboring homozygous deletion of the glycolytic enzyme enolase 1 (ENO1) are
selectively vulnerable to inhibition of the paralogous isoform, enolase 2 (ENO2). A previous …

Comparative pharmacology of a bis-pivaloyloxymethyl phosphonate prodrug inhibitor of enolase after oral and parenteral administration

VC Yan, Y Barekatain, YH Lin, N Satani… - ACS Pharmacology & …, 2023 - ACS Publications
Metabolically labile prodrugs can experience stark differences in catabolism incurred by the
chosen route of administration. This is especially true for phosph (on) ate prodrugs, in which …

The association of oxidative stress of neonatal hyperbilirubinemia and vitamin E supplementation

MZH Ahmed, RHAH Saad, A Gadalla… - Clinical and …, 2024 - termedia.pl
Results: Significant differences were found between the studied groups regarding serum
bilirubin on the third day of admission (p= 0.039). Patients who were treated with vitamin E …

[HTML][HTML] Anaplerotic nutrient stress drives synergy of angiogenesis inhibitors with therapeutics targeting tumor metabolism

S Khadka, YH Lin, J Ackroyd, YA Chen, Y Sheng… - bioRxiv, 2023 - ncbi.nlm.nih.gov
Tumor angiogenesis is a cancer hallmark, and its therapeutic inhibition has provided
meaningful, albeit limited, clinical benefit. While anti-angiogenesis inhibitors deprive the …