A systematic summary of survival and death signalling during the life of hair follicle stem cells

XM Hu, ZX Li, DY Zhang, YC Yang, S Fu… - Stem Cell Research & …, 2021 - Springer
Hair follicle stem cells (HFSCs) are among the most widely available resources and most
frequently approved model systems used for studying adult stem cells. HFSCs are …

FOXP3+ Treg as a therapeutic target for promoting anti-tumor immunity

TL Whiteside - Expert opinion on therapeutic targets, 2018 - Taylor & Francis
ABSTRACT Introduction: Regulatory T cells (Treg) characterized by expression of FOXP3
and strong immunosuppressive activity play a key role in regulating homeostasis in health …

Tissue Treg secretomes and transcription factors shared with stem cells contribute to a Treg niche to maintain Treg-ness with 80% innate immune pathways, and …

R Zhang, K Xu, Y Shao, Y Sun, J Saredy… - Frontiers in …, 2021 - frontiersin.org
We used functional-omics angles and examined transcriptomic heterogeneity in CD4+
Foxp3+ regulatory T cells (Treg) from spleen (s-Treg), lymph nodes (LN-Treg), intestine (int …

Stem cells, niches and scaffolds: applications to burns and wound care

SM Watt, JM Pleat - Advanced drug delivery reviews, 2018 - Elsevier
The importance of skin to survival, and the devastating physical and psychological
consequences of scarring following reparative healing of extensive or difficult to heal human …

Cell therapy for androgenetic alopecia: elixir or trick?

Y Mao, P Liu, J Wei, Y Xie, Q Zheng, R Li… - Stem Cell Reviews and …, 2023 - Springer
Androgenetic alopecia is the most common cause of hair loss aggravated by increased life
pressure, tension, and anxiety. Although androgenetic alopecia (AGA) does not significantly …

Anatomy and Physiology of the Skin

M Vestita, P Tedeschi, D Bonamonte - Textbook of plastic and …, 2022 - Springer
Human skin consists of a stratified, cellular epidermis and underlying dermis. Beneath the
dermis is a layer of subcutaneous fat separated from the rest of the body by a vestigial layer …

The potential of regulatory T cell-based therapies for alopecia areata

S Wan, W Xu, B Xie, C Guan, X Song - Frontiers in Immunology, 2023 - frontiersin.org
Cytotoxic T lymphocyte has been a concern for the etiopathogenesis of alopecia areata
(AA), some recent evidence suggests that the regulatory T (Treg) cell deficiency is also a …

An ROS‐Scavenging Treg‐Recruiting Hydrogel Patch for Diabetic Wound Healing

M Qu, W Xu, X Zhou, F Tang, Q Chen… - Advanced Functional …, 2024 - Wiley Online Library
Chronic inflammation and excessive reactive oxygen species (ROS) can impair diabetic
wound healing. Regulatory T cells (Tregs) have emerged as a promising target to promote …

Are hair follicle stem cells promising candidates for wound healing?

B Li, W Hu, K Ma, C Zhang, X Fu - Expert Opinion on Biological …, 2019 - Taylor & Francis
Introduction: With the continued focus on in-depth investigations of hair follicle stem cells
(HFSCs), the role of HFSCs in wound healing has attracted increasing attention from …

Spesolimab, the first‐in‐class anti‐IL‐36R antibody: From bench to clinic

A Morita, Y Okubo, S Imafuku… - The Journal of …, 2024 - Wiley Online Library
Inflammatory diseases that are driven by several pro‐inflammatory cytokines has resulted in
in the development of targeted therapies across different disease settings. Interleukin (IL)‐36 …