Quantifying postsynaptic receptor dynamics: insights into synaptic function

SA Maynard, J Ranft, A Triller - Nature Reviews Neuroscience, 2023 - nature.com
The molecular composition of presynaptic and postsynaptic neuronal terminals is dynamic,
and yet long-term stabilizations in postsynaptic responses are necessary for synaptic …

Identification of a stereotypic molecular arrangement of endogenous glycine receptors at spinal cord synapses

SA Maynard, P Rostaing, N Schaefer, O Gemin… - Elife, 2021 - elifesciences.org
Precise quantitative information about the molecular architecture of synapses is essential to
understanding the functional specificity and downstream signaling processes at specific …

Startle disease: new molecular insights into an old neurological disorder

N Schaefer, RJ Harvey, C Villmann - The Neuroscientist, 2023 - journals.sagepub.com
Startle disease (SD) is characterized by enhanced startle responses, generalized muscle
stiffness, unexpected falling, and fatal apnea episodes due to disturbed feedback inhibition …

Two-dimensional interfacial diffusion model of inhibitory synaptic receptor dynamics

PC Bressloff - Proceedings of the Royal Society A, 2023 - royalsocietypublishing.org
The diffusion-trapping of protein receptors in post-synaptic regions of a neuron's plasma
membrane plays a key role in determining the strength of synaptic connections and their …

Local accumulation times in a diffusion-trapping model of receptor dynamics at proximal axodendritic synapses

RD Schumm, PC Bressloff - Physical Review E, 2022 - APS
The lateral diffusion and trapping of neurotransmitter receptors within the postsynaptic
membrane of a neuron play a key role in determining synaptic strength and plasticity …

Cellular diffusion processes in singularly perturbed domains

PC Bressloff - Journal of Mathematical Biology, 2024 - Springer
There are many processes in cell biology that can be modeled in terms of particles diffusing
in a two-dimensional (2D) or three-dimensional (3D) bounded domain Ω⊂ R d containing a …

Nonequilibrium cluster-cluster aggregation in the presence of anchoring sites

R Baillou, J Ranft - Physical Review E, 2024 - APS
Nonequilibrium cluster-cluster aggregation of particles diffusing in or at the cell membrane
has been hypothesized to lead to domains of finite size in different biological contexts, such …

Inhibitory postsynaptic density from the lens of phase separation

G Bai, M Zhang - Oxford Open Neuroscience, 2022 - academic.oup.com
To faithfully transmit and decode signals released from presynaptic termini, postsynaptic
compartments of neuronal synapses deploy hundreds of various proteins. In addition to …

Identification of low copy synaptic glycine receptors in the mouse brain using single molecule localisation microscopy

S Camuso, Y Vella, SY Abadi, C Mille, B Brone… - bioRxiv, 2025 - biorxiv.org
Glycine receptors (GlyRs) are heteropentameric chloride channels that mediate fast
inhibitory neurotransmission in the brainstem and spinal cord, where they regulate motor …

Local accumulation times in a diffusion-trapping model of synaptic receptor dynamics

RD Schumm, PC Bressloff - arXiv preprint arXiv:2203.13126, 2022 - arxiv.org
The lateral diffusion and trapping of neurotransmitter receptors within the postsynaptic
membrane of a neuron plays a key role in determining synaptic strength and plasticity …