The mammalian target of rapamycin (mTOR) is a protein kinase that controls cellular
metabolism, catabolism, immune responses, autophagy, survival, proliferation, and …

Abstract Cyclin-dependent kinase 4 (CDK4) and CDK6 are critical mediators of cellular
transition into S phase and are important for the initiation, growth and survival of many …

Pharmacologic inhibitors of cyclin-dependent kinases 4 and 6 (CDK4/6) have recently
entered the therapeutic armamentarium of clinical oncologists, and show promising activity …

Stem cells are characterized by their ability to self-renew and differentiate into many different
cell types. Research has focused primarily on how these processes are regulated at a …

Pharmacological inhibitors of cyclin-dependent kinases 4 and 6 (CDK4/6) are now an
established standard of care for patients with advanced hormone receptor-positive breast …

During antibody affinity maturation, germinal center (GC) B cells cycle between affinity-
driven selection in the light zone (LZ) and proliferation and somatic hypermutation in the …

The ribosomal protein S6K (S6 kinase) represents an extensively studied effector of the
TORC1 [TOR (target of rapamycin) complex 1], which possesses important yet incompletely …

Inhibition of HER2 in HER2-amplified breast cancer has been remarkably successful
clinically, as demonstrated by the efficacy of HER-kinase inhibitors and HER2-antibody …

The process of translation requires substantial cellular resources. Cells have therefore
evolved complex mechanisms to control overall protein synthesis as well as the translation …

The evolutionarily conserved checkpoint protein kinase, TOR (target of rapamycin), has
emerged as a major effector of cell growth and proliferation via the regulation of protein …