Over the last three decades, the development of new genome editing techniques, such as
ODM, TALENs, ZFNs and the CRISPR‐Cas system, has led to significant progress in the …

Highlights•CRISPR-Cas9 is a powerful tool to modulate transcription in wide range of cell
types.•An expanding set of CRISPR-based transcription effectors is available.•Gene …

In this consensus paper resulting from a meeting that involved representatives from more
than 20 European partners, we recommend the foundation of an expert group (European …

The discovery and mechanistic understanding of target-specific genome engineering
technologies has led to extremely effective and specific genome editing in higher organisms …

There is a rapid increase of evidence to address the importance of the interaction between
single cells, drugs, and the response of single cells to therapies. Single-cell measurements …

Genome editing is a powerful suite of technologies utilized in basic and applied plant
research. Both nuclear and plastid genomes have been genetically engineered to alter traits …

Prokaryotes use diverse strategies to improve fitness in the face of different environmental
threats and stresses, including those posed by mobile genetic elements (eg, bacteriophages …

Given the large amount of genome-wide data that have been collected during the last
decades, a good understanding of how and why cells change during development …

Clustered regularly interspaced short palindromic repeats/CRISPR-associated (Cas)
proteins (CRISPR/Cas) is an adaptive immunity system in bacterial and archaeal groups for …

CRISPR/Cas system, a newly but extensively investigated genome-editing method, harbors
practical solutions for various genetic problems. It relies on short guide RNAs (gRNAs) to …