Animal work over the last three decades has generated a convincing body of evidence that a
Western diet–one high in saturated fat and refined carbohydrates (HFS diet)–can damage …

Functional integrity of the vascular endothelium is of fundamental importance for normal
vascular function. A key factor regulating endothelial function is the bioavailability of nitric …

There is growing evidence that obesity has deleterious effects on the brain and cognitive
function in the elderly population. However, the specific mechanisms through which aging …

Neuroinflammation is a common pathological event observed in many different brain
diseases, frequently associated with blood brain barrier (BBB) dysfunction and followed by …

The recent guidelines for cardiovascular prevention released by the American College of
Cardiology/American Heart Association (2019) state that counseling on sleep and sleep …

Recent clinical data indicates that hemodynamic changes caused by cardiovascular
diseases such as atherosclerosis, heart failure, and hypertension affect cognition. Yet, the …

Alzheimer's disease (AD) is an irredeemable chronic neurodegenerative disorder and the
predominant cause of dementia. The disease progression is associated with the deposition …

Adipose tissue is an active metabolic organ that contributes to processes such as energy
storage and utilization and to the production of a number of metabolic agents, such as …

Background Recent studies indicate that maternal exposure to ambient ultrafine particles
and nanoparticles has adverse effects of on the central nervous system. Quantitative dose …

Non-alcoholic fatty liver disease (NAFLD) is by now the most prevalent liver disease
worldwide. The non-proteogenic amino acid l-citrulline (L-Cit) has been shown to protect …