Erectile dysfunction (ED), generally associated with reduced sexual desire and sometimes
with orgasmic or ejaculatory dysfunction, is the major revealing symptom of …

Background We examined whether vasodilator responses to β-agonists in human forearm
vasculature are mediated in part through the nitric oxide pathway. Methods and Results We …

It is now almost 30 years since the discovery that prostaglandin E 1 (PGE 1) inhibits platelet
responses to aggregating agents, together with finding that the effects of this compound are …

Isoprenaline (3 x 10 (-8)-10 (-5) M), salbutamol (3 x 10 (-7)-10 (-4) M) and forskolin (3 x 10 (-
9)-3 x 10 (-7) M) relaxed rat isolated thoracic aortic rings contracted with noradrenaline (10 …

Publisher Summary The elevation of cyclic guanosine monophosphate (GMP) within smooth
muscle leads to relaxation. This elevation can be the result of the activity of two distinct …

Atherosclerosis involves cellular immune responses and altered vascular smooth muscle
cell (VSMC) function. Nitric oxide (NO)/cGMP is uniquely capable of inhibiting key processes …

The establishment of a Gordon Research Conference devoted to cyclic nucleotide
phosphodiesterases has had an enormous impact on the field by facilitating collaborations …

1 The effects of selective inhibitors of adenosine 3′: 5′‐cyclic monophosphate (cyclic
AMP) and guanosine 3′: 5′‐cyclic monophosphate (cyclic GMP) phosphodiesterases …

1 The vasorelaxant activity of isoliquiritigenin, isolated from Dalbergia odor if era T., was
investigated in the phenylephrine‐precontracted rat aorta by measuring tension, guanylate …

Objectives. To further investigate the mechanism of action of sildenafil, a selective inhibitor
of cyclic guanosine monophosphate (cGMP)-specific phosphodiesterase 5 (PDE5), that has …