Evaluation and targeting of amyloid precursor protein (APP)/amyloid beta (Aβ) axis in amyloidogenic and non-amyloidogenic pathways: A time outside the tunnel
In Alzheimer disease (AD), amyloid precursor protein (APP) and production of amyloid beta
(Aβ) which is generated by amyloidogenic pathway is implicated in neurotoxicity and …
(Aβ) which is generated by amyloidogenic pathway is implicated in neurotoxicity and …
Blood-brain barrier disruption: a culprit of cognitive decline?
J Che, Y Sun, Y Deng, J Zhang - Fluids and Barriers of the CNS, 2024 - Springer
Cognitive decline covers a broad spectrum of disorders, not only resulting from brain
diseases but also from systemic diseases, which seriously influence the quality of life and …
diseases but also from systemic diseases, which seriously influence the quality of life and …
The duality of amyloid-β: its role in normal and Alzheimer's disease states
A Azargoonjahromi - Molecular Brain, 2024 - Springer
Alzheimer's disease (AD) is a degenerative neurological condition that gradually impairs
cognitive abilities, disrupts memory retention, and impedes daily functioning by impacting …
cognitive abilities, disrupts memory retention, and impedes daily functioning by impacting …
Current pharmacophore based approaches for the development of new anti-Alzheimer's agents
Amyloid beta peptide (Aβ) and hyperphosphorylated neuronal tau proteins accumulate in
neurofibrillary tangles in Alzheimer's disease (AD), a chronic neurodegenerative illness …
neurofibrillary tangles in Alzheimer's disease (AD), a chronic neurodegenerative illness …
The Multifaceted Role of L-Type Amino Acid Transporter 1 at the Blood–Brain Barrier: Structural Implications and Therapeutic Potential
HS Ahmed - Molecular Neurobiology, 2024 - Springer
L-type amino acid transporter 1 (LAT1) is integral to the transport of large neutral amino
acids across the blood–brain barrier (BBB), playing a crucial role in brain homeostasis and …
acids across the blood–brain barrier (BBB), playing a crucial role in brain homeostasis and …
Isolation method of brain microvessels from small frozen human brain tissue for blood-brain barrier protein expression analysis
Background Protein expression analysis of isolated brain microvessels provides valuable
insights into the function of the blood-brain barrier (BBB). However, isolation of brain …
insights into the function of the blood-brain barrier (BBB). However, isolation of brain …
[HTML][HTML] Is the Relationship Between Cardiovascular Disease and Alzheimer's Disease Genetic? A Scoping Review
A Moore, MD Ritchie - Genes, 2024 - mdpi.com
Background/Objectives: Cardiovascular disease (CVD) and Alzheimer's disease (AD) are
two diseases highly prevalent in the aging population and often co-occur. The exact …
two diseases highly prevalent in the aging population and often co-occur. The exact …
Progressive Amyloid-β Accumulation in the Brain leads to Altered Protein Expressions in the Liver and Kidneys of APP knock-in Mice
S Ito, Y Iwata, M Otsuka, Y Kaneko, S Ogata… - Journal of …, 2024 - Elsevier
Impaired hepatic and renal function influence Alzheimer's disease (AD) progression;
however, whether AD progression affects these important organ functions remains unclear …
however, whether AD progression affects these important organ functions remains unclear …
Transferrin receptor-mediated transport at the blood-brain barrier is elevated in early development but maintained across adult aging
VO Torres, ME Pizzo, D Chan, JC Dugas, D Huynh… - bioRxiv, 2024 - biorxiv.org
Transferrin receptor (TfR)-mediated transcytosis across the blood-brain barrier (BBB) is a
promising strategy to improve delivery of biologics to the central nervous system (CNS) …
promising strategy to improve delivery of biologics to the central nervous system (CNS) …
阿尔茨海默病与血脑屏障的相关性研究进展
申杰， 徐桂华 - 实用医学杂志, 2024 - syyxzz.com
大量研究已证实阿尔茨海默病是一种血脑屏障(BBB) 功能障碍相关性疾病, 如何通过恢复BBB
结构完整性, 改善其生理机能, 提高AD 的转归和预后, 必将为该慢病的预防与治疗带来新的视角 …
结构完整性, 改善其生理机能, 提高AD 的转归和预后, 必将为该慢病的预防与治疗带来新的视角 …