The marine environment is an excellent source of molecules that have a wide structural
diversity and a variety of biological activities. Many marine natural products (MNPs) have …

A new series of nortopsentin analogs, in which the central imidazole ring of the natural lead
was replaced by a 1, 3, 4-oxadiazole or 1, 3, 4-thiadiazole moiety, was efficiently …

Proliferating cancer cells are characterized by the Warburg effect, a metabolic alteration in
which ATP is generated from cytoplasmic glycolysis instead of oxidative phosphorylation …

Cancer is a major societal, public health, and economic burden in the 21 st century, with 9.7
million deaths in 2022 (9.96 million in 2020) and 20 million new cancer cases (19.6 million …

Bioactive compounds are abundant in animals originating from marine ecosystems. Ion
channels, which include sodium, potassium, calcium, and chloride, together with their …

Natural products as starting templates have shown historically major contribution to
development of drugs. Inspired by the structure–function of an anticancer natural alkaloid …

Breast cancer is a major threat to women's health worldwide. Although the 5-year survival
rate is relatively high, treating recurrent and metastatic breast cancer remains challenging …

Tuberculosis, a persistent illness caused by Mycobacterium tuberculosis, remains a
significant global public health challenge. The widespread use of anti-tuberculosis drugs …

Less than half of all patients diagnosed with pancreatic ductal adenocarcinoma (PDAC)
respond to chemotherapy, and the prognosis of PDAC is poor, which may be mediated by …

Despite improvements in overall cancer mortality, deaths related to pancreatic cancer
continue to rise. Following first-line treatment, second-line options are significantly limited …