Berberine is a plant metabolite belonging to the group of isoquinoline alkaloids with strong
biological and pharmacological activity. Currently, berberine is receiving considerable …

c-Jun N-terminal kinases (JNKs) are a family of protein kinases that play a central role in
stress signaling pathways implicated in gene expression, neuronal plasticity, regeneration …

The mammalian family of mitogen-activated protein kinases (MAPKs) includes extracellular
signal-regulated kinase (ERK), p38, and c-Jun NH2-terminal kinase (JNK), with each MAPK …

Antiviral drugs have traditionally been developed by directly targeting essential viral
components. However, this strategy often fails due to the rapid generation of drug-resistant …

Diabetic nephropathy (DN), a chronic complication of diabetes, is charecterized by
glomerular hypertrophy, proteinuria, decreased glomerular filtration, and renal fibrosis …

Cancers arise owing to mutations in a subset of genes that confer growth advantage. The
availability of the human genome sequence led us to propose that systematic resequencing …

Diabetic nephropathy is the leading cause of end‐stage kidney disease worldwide but
current treatments remain suboptimal. This review examines the evidence for inflammation …

Excessive inflammation is becoming accepted as a critical factor in many human diseases,
including inflammatory and autoimmune disorders, neurodegenerative conditions, infection …

Neonatal hypoxic ischemic encephalopathy (HIE) is a devastating disease that primarily
causes neuronal and white matter injury and is among the leading cause of death among …

c-Jun N-terminal kinases (JNKs), also referred to as stress-activated kinases (SAPKs), were
initially characterized by their activation in response to cell stress such as UV irradiation …