Candidate biomarkers in psychiatric disorders: state of the field
The field of psychiatry is hampered by a lack of robust, reliable and valid biomarkers that can
aid in objectively diagnosing patients and providing individualized treatment …
aid in objectively diagnosing patients and providing individualized treatment …
Executive function in autism spectrum disorder: history, theoretical models, empirical findings, and potential as an endophenotype
This review presents an outline of executive function (EF) and its application to autism
spectrum disorder (ASD). The development of the EF construct, theoretical models of EF …
spectrum disorder (ASD). The development of the EF construct, theoretical models of EF …
The neuropathology of autism: A systematic review of post-mortem studies of autism and related disorders
R Fetit, RF Hillary, DJ Price, SM Lawrie - Neuroscience & Biobehavioral …, 2021 - Elsevier
Post-mortem studies allow for the direct investigation of brain tissue in those with autism and
related disorders. Several review articles have focused on aspects of post-mortem …
related disorders. Several review articles have focused on aspects of post-mortem …
Neuroimaging genetics approaches to identify new biomarkers for the early diagnosis of autism spectrum disorder
Autism-spectrum disorders (ASDs) are developmental disabilities that manifest in early
childhood and are characterized by qualitative abnormalities in social behaviors …
childhood and are characterized by qualitative abnormalities in social behaviors …
Increased prefrontal GABA concentrations in adults with autism spectrum disorders
S Maier, AL Düppers, K Runge, M Dacko… - Autism …, 2022 - Wiley Online Library
The excitatory‐inhibitory imbalance hypothesis postulates dysregulation of the gamma‐
aminobutyric acid (GABA) and glutamate (Glu) neurotransmitter systems as a common …
aminobutyric acid (GABA) and glutamate (Glu) neurotransmitter systems as a common …
Region-specific elevations of glutamate+ glutamine correlate with the sensory symptoms of autism spectrum disorders
Individuals on the autism spectrum are often reported as being hyper-and/or hyporeactive to
sensory input. These sensory symptoms were one of the key observations that led to the …
sensory input. These sensory symptoms were one of the key observations that led to the …
Increased glutamate and glutamine levels and their relationship to astrocytes and dopaminergic transmissions in the brains of adults with autism
Increased excitatory neuronal tones have been implicated in autism, but its mechanism
remains elusive. The amplified glutamate signals may arise from enhanced glutamatergic …
remains elusive. The amplified glutamate signals may arise from enhanced glutamatergic …
Prediction learning in adults with autism and its molecular correlates
LA Sapey-Triomphe, J Temmerman, NAJ Puts… - Molecular autism, 2021 - Springer
Abstract Background According to Bayesian hypotheses, individuals with Autism Spectrum
Disorder (ASD) have difficulties making accurate predictions about their environment. In …
Disorder (ASD) have difficulties making accurate predictions about their environment. In …
From bench to bedside: The mGluR5 system in people with and without Autism Spectrum Disorder and animal model systems
C Carey, N Singh, JT Dunn, T Sementa… - Translational …, 2022 - nature.com
The metabotropic glutamate receptor 5 (mGluR5) is a key regulator of excitatory (E)
glutamate and inhibitory (I) γ-amino butyric acid (GABA) signalling in the brain. Despite the …
glutamate and inhibitory (I) γ-amino butyric acid (GABA) signalling in the brain. Despite the …
[HTML][HTML] Inhibitory dysfunction and social processing difficulties in autism: A comprehensive narrative review
The primary inhibitory neurotransmitter γ-aminobutyric acid (GABA) has a prominent role in
regulating neural development and function, with disruption to GABAergic signalling linked …
regulating neural development and function, with disruption to GABAergic signalling linked …