Early life stressors display a high universal prevalence and constitute a major public health
problem. Prolonged psychoneurobiological alterations as sequelae of early life stress (ELS) …

In the past two decades, much evidence has accumulated unequivocally demonstrating that
child abuse and neglect is associated with a marked increase in risk for major psychiatric …

Exposures to adverse environments, both psychosocial and physicochemical, are prevalent
and consequential across a broad range of childhood populations. Such adversity …

BackgroundThe aim of this study was to build a detailed, integrative profile of the correlates
of young adults' feelings of loneliness, in terms of their current health and functioning and …

Background: Studies investigating the impact of a variety of inflammatory stimuli on the brain
and behavior have reported evidence that inflammation and release of inflammatory …

Major life stressors, especially those involving interpersonal stress and social rejection, are
among the strongest proximal risk factors for depression. In this review, we propose a …

Children who experience chronic stressors are vulnerable to emotional and physical health
problems across the lifespan. This phenomenon raises questions for scientists and …

Studies over the last 20 years have demonstrated that increased inflammation and
hyperactivity of the hypothalamic–pituitary–adrenal (HPA) axis are two of the most consistent …

In the 2011 “Expert Panel on Integrated Guidelines for Cardiovascular Health and Risk
Reduction in Children and Adolescents,” several medical conditions among youth were …

The brain and the immune system are not fully formed at birth, but rather continue to mature
in response to the postnatal environment. The two-way interaction between the brain and …