[HTML][HTML] The storage and in-use stability of mRNA vaccines and therapeutics: not a cold case
EO Blenke, E Örnskov, C Schöneich, GA Nilsson… - Journal of …, 2023 - Elsevier
The remarkable impact of mRNA vaccines on mitigating disease and improving public
health has been amply demonstrated during the COVID-19 pandemic. Many new mRNA …
health has been amply demonstrated during the COVID-19 pandemic. Many new mRNA …
Membrane technology for the purification of RNA and DNA therapeutics
Nucleic acid therapeutics have the potential to revolutionize the biopharmaceutical industry,
providing highly effective vaccines and novel treatments for cancers and genetic disorders …
providing highly effective vaccines and novel treatments for cancers and genetic disorders …
Characterization and associated pressure-dependent behavior of deposits formed during sterile filtration of mRNA-Lipid nanoparticles
The recent success of mRNA vaccines has generated increased interest in the use of Lipid
Nanoparticles (LNPs) for delivery of nucleic acids. The objective of this study was to …
Nanoparticles (LNPs) for delivery of nucleic acids. The objective of this study was to …
Lipid Nanoparticle (LNP) Delivery Carrier-Assisted Targeted Controlled Release mRNA Vaccines in Tumor Immunity
L Wu, X Li, X Qian, S Wang, J Liu, J Yan - Vaccines, 2024 - mdpi.com
In recent years, lipid nanoparticles (LNPs) have attracted extensive attention in tumor
immunotherapy. Targeting immune cells in cancer therapy has become a strategy of great …
immunotherapy. Targeting immune cells in cancer therapy has become a strategy of great …
Review of machine learning for lipid nanoparticle formulation and process development
Lipid nanoparticles (LNPs) are a subset of pharmaceutical nanoparticulate formulations
designed to encapsulate, stabilize, and deliver nucleic acid cargoes in vivo. Applications for …
designed to encapsulate, stabilize, and deliver nucleic acid cargoes in vivo. Applications for …
Ultrafast continuous flow-dialysis for nanoparticle-based drug delivery systems via microfluidic-multiple buffer injector
Nanoparticle-based drug delivery systems (NP-DDS) have emerged as promising carriers
for bioactive organic molecules due to their potential in enhancing therapeutic effects …
for bioactive organic molecules due to their potential in enhancing therapeutic effects …
An Experimental and Modeling Approach to Study Tangential Flow Filtration Performance for mRNA Drug Substance Purification
E Nourafkan, C Kenyon, A Nair… - Biotechnology …, 2024 - Wiley Online Library
Following the recent COVID‐19 pandemic, mRNA manufacturing processes are being
actively developed and optimized to produce the next generation of mRNA vaccines and …
actively developed and optimized to produce the next generation of mRNA vaccines and …
Productivity and energy consumption as performance criteria to overcome bias caused by membrane resistance
Membrane scientists and engineers routinely compare the performance of membranes for
different applications. Such comparisons are required to optimize surface chemistries and to …
different applications. Such comparisons are required to optimize surface chemistries and to …
Flux and fouling behavior during constant pressure sterile filtration of nanoemulsions
Nanoemulsions with droplet diameters from 20 to 200 nm have emerged as attractive
adjuvants in the development of novel vaccines and as an advanced method of drug …
adjuvants in the development of novel vaccines and as an advanced method of drug …
Development of a New Modeling Framework to Describe Sterile Filtration of mRNA-Lipid Nanoparticles
Sterile filtration is one of the critical steps in the production of lipid nanoparticle (LNP)-based
biotherapeutics. However, LNP fouling can limit the overall capacity of the sterilizing-grade …
biotherapeutics. However, LNP fouling can limit the overall capacity of the sterilizing-grade …