Acid sphingomyelinase deficiency (ASMD) is a lysosomal storage disease caused by
deficient activity of acid sphingomyelinase (ASM) enzyme, leading to the accumulation of …

The concept of proper resolution of inflammation rather than counteracting it, gained a lot of
attention in the past few years. Re-assembly of tissue and cell homeostasis as well as …

T helper 17 (TH17) cells are implicated in autoimmune diseases, and several metabolic
processes are shown to be important for their development and function. In this study, we …

Introduction Cystic fibrosis (CF), especially CF lung disease, is characterized by chronic
infection, immune dysfunction including impairment of regulatory T cells (Tregs) and an …

The dura sinus-resident immune cells can influence the process of central neural system
(CNS) diseases by communicating with central nerve cells. In clinical, Tregs are also …

Sphingolipid dysregulation is involved in a range of rare and fatal diseases as well as
common pathologies including cancer, infectious diseases or neurodegeneration. Gaining …

Background At diagnosis of Type 1 Diabetes (T1D), 30% of the beta cells are dormant, ie
alive, but inactive. This could reduce beta cell destruction, as cellular stress contributes to …

Sphingolipids, associated enzymes, and the sphingolipid pathway are implicated in
complex, multifaceted roles impacting several cell functions, such as cellular homeostasis …

Western diet (WD), high in sugar and fat, promotes obesity and associated chronic low-
grade pro-inflammatory environment, leading to impaired immune function, reprogramming …

Acid sphingomyelinase (Asm) and acid ceramidase (Ac) are parts of the sphingolipid
metabolism. Asm hydrolyzes sphingomyelin to ceramide, which is further metabolized to …