The anti-inflammatory and immunomodulatory activities of natural products to control autoimmune inflammation

KD Moudgil, SH Venkatesha - International journal of molecular sciences, 2022 - mdpi.com
Inflammation is an integral part of autoimmune diseases, which are caused by dysregulation
of the immune system. This dysregulation involves an imbalance between pro-inflammatory …

The many facets of macrophages in rheumatoid arthritis

E Siouti, E Andreakos - Biochemical pharmacology, 2019 - Elsevier
Macrophages are central to the pathophysiology of rheumatoid arthritis (RA). They constitute
the main source of pro-inflammatory cytokines and chemokines such as TNF and IL-1β, they …

[HTML][HTML] Interleukin-17 promotes autoimmunity by triggering a positive-feedback loop via interleukin-6 induction

H Ogura, M Murakami, Y Okuyama, M Tsuruoka… - Immunity, 2008 - cell.com
Dysregulated cytokine expression and signaling are major contributors to a number of
autoimmune diseases. Interleukin-17A (IL-17A) and IL-6 are important in many disorders …

GM-CSF and CXCR4 define a T helper cell signature in multiple sclerosis

E Galli, FJ Hartmann, B Schreiner, F Ingelfinger… - Nature medicine, 2019 - nature.com
Cytokine dysregulation is a central driver of chronic inflammatory diseases such as multiple
sclerosis (MS). Here, we sought to determine the characteristic cellular and cytokine …

Anti-inflammatory compounds of plant origin. Part II. Modulation of pro-inflammatory cytokines, chemokines and adhesion molecules

JB Calixto, MM Campos, MF Otuki… - Planta medica, 2004 - thieme-connect.com
It has been widely shown that many plant-derived compounds present significant anti-
inflammatory effects. For this reason, they represent potential molecules for the development …

ABO blood group and risk of coronary heart disease in two prospective cohort studies

M He, B Wolpin, K Rexrode, JAE Manson… - … , and vascular biology, 2012 - Am Heart Assoc
Objective—Epidemiological data regarding the association between ABO blood groups and
risk of coronary heart disease (CHD) have been inconsistent. We sought to investigate the …

KLF2 in regulation of NF-κB-mediated immune cell function and inflammation

P Jha, H Das - International journal of molecular sciences, 2017 - mdpi.com
KLF2 (Kruppel-like factor 2) is a member of the zinc finger transcription factor family, which
critically regulates embryonic lung development, function of endothelial cells and …

Leptin and nutrition in gestational diabetes

A Pérez-Pérez, T Vilariño-García, P Guadix, JL Dueñas… - Nutrients, 2020 - mdpi.com
Leptin is highly expressed in the placenta, mainly by trophoblastic cells, where it has an
important autocrine trophic effect. Moreover, increased leptin levels are found in the most …

Inflammation-associated cancer: NF-κB is the lynchpin

Q Li, S Withoff, IM Verma - Trends in immunology, 2005 - cell.com
It has long been suspected that NF-κB signaling has a pivotal role in chronic inflammation-
associated malignancies, although genetic evidence for this hypothesis has been lacking …

Pharmacological inhibition of nicotinamide phosphoribosyltransferase/visfatin enzymatic activity identifies a new inflammatory pathway linked to NAD

N Busso, M Karababa, M Nobile, A Rolaz, F Van Gool… - PloS one, 2008 - journals.plos.org
Nicotinamide phosphoribosyltransferase (NAMPT), also known as visfatin, is the rate-limiting
enzyme in the salvage pathway of NAD biosynthesis from nicotinamide. Since its expression …