Etiology of type 1 diabetes

JA Todd - Immunity, 2010 - cell.com
Recent genetic mapping and gene-phenotype studies have revealed the genetic
architecture of type 1 diabetes. At least ten genes so far can be singled out as strong causal …

Human renalase: a review of its biology, function, and implications for hypertension

GV Desir, L Wang, AJ Peixoto - Journal of the American Society of …, 2012 - Elsevier
Renalase is a novel flavoprotein, highly expressed in kidney and heart, which metabolizes
catecholamines and catecholamine-like substances via a superoxide (O2–)-dependent …

[HTML][HTML] Renalase protects the cardiomyocytes of Sprague-Dawley rats against ischemia and reperfusion injury by reducing myocardial cell necrosis and apoptosis

X Li, Z Xie, M Lin, R Huang, Z Liang, W Huang… - Kidney and Blood …, 2015 - karger.com
Background/Aims: Renalase, a novel flavoprotein expressed in the kidney and heart,
reduces renal tubular necrosis and apoptosis, which suggests that it might protect against …

Renalase lowers ambulatory blood pressure by metabolizing circulating adrenaline

GV Desir, LQ Tang, P Wang, G Li… - Journal of the …, 2012 - Am Heart Assoc
Background Blood pressure is acutely regulated by the sympathetic nervous system through
the action of vasoactive hormones such as epinephrine, norepinephrine, and dopamine …

Renalase in hypertension and kidney disease

GV Desir, AJ Peixoto - Nephrology dialysis transplantation, 2014 - academic.oup.com
Renalase, a recently discovered flavoprotein, which is strongly expressed in the kidney and
heart, effectively metabolizes catecholamines. It was discovered during the search to identify …

Renalase prevents AKI independent of amine oxidase activity

L Wang, H Velazquez, G Moeckel… - Journal of the …, 2014 - journals.lww.com
AKI is characterized by increased catecholamine levels and hypertension. Renalase, a
secretory flavoprotein that oxidizes catecholamines, attenuates ischemic injury and the …

Exercise differentially regulates renalase expression in skeletal muscle and kidney

B Czarkowska-Paczek… - The Tohoku Journal of …, 2013 - jstage.jst.go.jp
Renalase is a newly discovered amine oxidase and may lower blood pressure by
metabolizing catecholamines. We have hypothesized that exercise and training may …

FAD-binding site and NADP reactivity in human renalase: a new enzyme involved in blood pressure regulation

M Milani, F Ciriello, S Baroni, V Pandini… - Journal of molecular …, 2011 - Elsevier
Renalase is a recently discovered flavoprotein that regulates blood pressure, regulates
sodium and phosphate excretion, and displays cardioprotectant action through a …

Renalase protects against renal fibrosis by inhibiting the activation of the ERK signaling pathways

Y Wu, L Wang, D Deng, Q Zhang, W Liu - International journal of …, 2017 - mdpi.com
Renal interstitial fibrosis is a common pathway for the progression of chronic kidney disease
(CKD) to end-stage renal disease. Renalase, acting as a signaling molecule, has been …

Metabolic function for human renalase: oxidation of isomeric forms of β-NAD (P) H that are inhibitory to primary metabolism

BA Beaupre, MR Hoag, J Roman, FH Försterling… - Biochemistry, 2015 - ACS Publications
Renalase is a recently identified flavoprotein that has been associated with numerous
physiological maladies. There remains a prevailing belief that renalase functions as a …