In the past three decades, the ability to optically manipulate biomolecules has spurred a new
era of medical and biophysical research. Optical tweezers (OT) have enabled experimenters …

The separation of sister chromatids during anaphase is the culmination of mitosis and one of
the most strikingly beautiful examples of cellular movement. It consists of two distinct …

Accurate segregation of chromosomes relies on the force-bearing capabilities of the
kinetochore to robustly attach chromosomes to dynamic microtubule tips. The human Ska …

To form functional kinetochores, CENP-C and CENP-T independently recruit the KMN
(Knl1C, Mis12C, and Ndc80C) network onto the kinetochores. To clarify the functions of the …

Over the past two decades, single-molecule techniques have evolved into robust tools to
study many fundamental biological processes. The combination of optical tweezers with …

The imbalance of kinetochore-microtubule attachment during cell mitosis is a response to
the initiation and progression of human cancers. Spindle component 25 (SPC25) is …

The kinetochore is an essential structure for the chromosome segregation machinery in
eukaryotes; it serves as a bridge between the spindle microtubules and chromosomes. The …

Partitioning of the genome requires kinetochores, large protein complexes that mediate
dynamic attachment of chromosomes to the spindle. Kinetochores contain two …

Proper chromosome segregation is crucial for cell division. In eukaryotes, this is achieved by
the kinetochore, an evolutionarily conserved multiprotein complex that physically links the …

Strong kinetochore-microtubule attachments are essential for faithful segregation of sister
chromatids during mitosis. The Dam1 and Ndc80 complexes are the main microtubule …