Sarcopenia is a systemic disease with progressive and generalized skeletal muscle
dysfunction defined by age-related low muscle mass, high content of muscle slow fibers, and …

A large number of putative cis-regulatory sequences have been annotated in the human
genome, but the genes they control remain poorly defined. To bridge this gap, we generate …

Background Polycystic ovary syndrome (PCOS) is a common, complex genetic disorder
affecting up to 15% of reproductive-age women worldwide, depending on the diagnostic …

Psoriasis and coronary artery disease (CAD) are related comorbidities that are well
established, but whether a genetic basis underlies this is not well studied. We apply trans …

The three-dimensional structure of the human genome has been proven to have a
significant functional impact on gene expression. The high-order spatial chromatin is …

Establishing causal links between inherited polymorphisms and cancer risk is challenging.
Here, we focus on the single-nucleotide polymorphism rs55705857, which confers a sixfold …

Abstract The 2018 Nucleic Acids Research Database Issue contains 181 papers spanning
molecular biology. Among them, 82 are new and 84 are updates describing resources that …

Although genome-wide association studies (GWAS) have identified more than 100
colorectal cancer risk loci, most of the biological mechanisms associated with these loci …

The regulatory effect of non-coding large-scale structural variations (SVs) on proto-
oncogene activation remains unclear. This study investigated SV-mediated gene …

Impaired neuronal processes, including dopamine imbalance, are central to the
pathogenesis of major psychosis, but the molecular origins are unclear. Here we perform a …