Formation and integration of new neurons in the adult hippocampus
A Denoth-Lippuner, S Jessberger - Nature Reviews Neuroscience, 2021 - nature.com
Neural stem cells (NSCs) generate new neurons throughout life in the mammalian brain.
Adult-born neurons shape brain function, and endogenous NSCs could potentially be …
Adult-born neurons shape brain function, and endogenous NSCs could potentially be …
The single-cell sequencing: new developments and medical applications
Single-cell sequencing technologies can be used to detect the genome, transcriptome and
other multi-omics of single cells. They can show the differences and evolutionary …
other multi-omics of single cells. They can show the differences and evolutionary …
Single-cell genome sequencing of human neurons identifies somatic point mutation and indel enrichment in regulatory elements
Accurate somatic mutation detection from single-cell DNA sequencing is challenging due to
amplification-related artifacts. To reduce this artifact burden, an improved amplification …
amplification-related artifacts. To reduce this artifact burden, an improved amplification …
Cancer-associated mutations in endometriosis without cancer
MS Anglesio, N Papadopoulos, A Ayhan… - … England Journal of …, 2017 - Mass Medical Soc
Background Endometriosis, defined as the presence of ectopic endometrial stroma and
epithelium, affects approximately 10% of reproductive-age women and can cause pelvic …
epithelium, affects approximately 10% of reproductive-age women and can cause pelvic …
Neuronal subtypes and diversity revealed by single-nucleus RNA sequencing of the human brain
The human brain has enormously complex cellular diversity and connectivities fundamental
to our neural functions, yet difficulties in interrogating individual neurons has impeded …
to our neural functions, yet difficulties in interrogating individual neurons has impeded …
Revealing the vectors of cellular identity with single-cell genomics
Single-cell genomics has now made it possible to create a comprehensive atlas of human
cells. At the same time, it has reopened definitions of a cell's identity and of the ways in …
cells. At the same time, it has reopened definitions of a cell's identity and of the ways in …
Genetic studies in intellectual disability and related disorders
Genetic factors play a major part in intellectual disability (ID), but genetic studies have been
complicated for a long time by the extreme clinical and genetic heterogeneity. Recently …
complicated for a long time by the extreme clinical and genetic heterogeneity. Recently …
Single-cell transcriptomics meets lineage tracing
L Kester, A Van Oudenaarden - Cell stem cell, 2018 - cell.com
Reconstructing lineage relationships between cells within a tissue or organism is a long-
standing aim in biology. Traditionally, lineage tracing has been achieved through the …
standing aim in biology. Traditionally, lineage tracing has been achieved through the …
Mechanisms of DNA damage‐mediated neurotoxicity in neurodegenerative disease
G Welch, LH Tsai - EMBO reports, 2022 - embopress.org
Neurons are highly susceptible to DNA damage accumulation due to their large energy
requirements, elevated transcriptional activity, and long lifespan. While newer research has …
requirements, elevated transcriptional activity, and long lifespan. While newer research has …
Advances and applications of single-cell sequencing technologies
Single-cell sequencing (SCS) has emerged as a powerful new set of technologies for
studying rare cells and delineating complex populations. Over the past 5 years, SCS …
studying rare cells and delineating complex populations. Over the past 5 years, SCS …