Cancer is considered an age-related disease that, over the next 10 years, will become the
most prevalent health problem worldwide. Although cancer therapy has remarkably …

Autophagy is a major catabolic pathway in a eukaryotic cell, employed for cellular self-
degradation of obsolete or damaged cytoplasmic components serving as a major quality …

Autophagy is a cellular catabolic process responsible for the degradation of cytoplasmic
constituents, including organelles and long-lived proteins, that helps maintain cellular …

Protoporphyrin IX (PpIX) is an endogenous fluorescent molecule that selectively
accumulates in cancer cells treated with the heme precursor 5-aminolevulinic acid (5-ALA) …

Aminolevulinic acid (ALA)‐mediated protoporphyrin IX (Pp IX) production is being explored
for tumor fluorescence imaging and photodynamic therapy (PDT). As a prodrug, ALA is …

Significance: We demonstrate that clinically used kinase inhibitors such as lapatinib can be
used for enhancing aminolevulinic acid (ALA) for tumor fluorescence imaging and …

The Mechanistic or Mammalian Target of Rapamycin (mTOR) is a major signaling pathway
in eukaryotic cells belonging to the P13K-related kinase family of the serine/threonine …

Aminolevulinic acid (ALA) is a prodrug that is metabolized in the heme biosynthesis pathway
to produce protoporphyrin IX (Pp IX) for tumor fluorescence detection and photodynamic …

Vascular-targeted photodynamic therapy (PDT) selectively disrupts vascular function by
inducing oxidative damages to the vasculature, particularly endothelial cells. Although …

Enhanced protoporphyrin IX (PpIX) production in tumors derived from the administration of 5-
aminolevulinic acid (ALA) enables the use of ALA as a prodrug for photodynamic therapy …