Gli proteins are transcriptional effectors of the Hedgehog signaling pathway. They play key
roles in the development of many organs and tissues, and are deregulated in birth defects …

The formation of a hierarchical vascular network, composed of arteries, veins, and
capillaries, is essential for embryogenesis and is required for the production of new …

Injured skeletal muscle regenerates, but with age or in muscular dystrophies, muscle is
replaced by fat. Upon injury, muscle-resident fibro/adipogenic progenitors (FAPs) …

Primary cilia are immotile appendages that have evolved to receive and interpret a variety of
different extracellular cues. Cilia play crucial roles in intercellular communication during …

Blood flow and vascular shear stress patterns play a significant role in inducing and
modulating physiological responses of endothelial cells (ECs). Pulsatile shear (PS) is …

Hedgehog (Hh) signaling is evolutionarily conserved and plays an instructional role in
embryonic morphogenesis, organogenesis in various animals, and the central nervous …

A fundamental problem in tissue morphogenesis is identifying how subcellular signaling
regulates mesoscale organization of tissues. The primary cilium is a paradigmatic organelle …

Loss of limbs evolved many times in squamate reptiles. Here we investigated the genomic
basis of convergent limb loss in reptiles. We sequenced the genomes of a closely related …

Cellular responses to the graded Sonic Hedgehog (Shh) morphogenic signal are
orchestrated by three Gli genes that give rise to both transcription activators and repressors …

The SHH signaling pathway is essential for proper formation of the limb skeleton, as is
required for the survival and expansion of distal chondrogenic progenitor cells. At the same …