[HTML][HTML] Limitations and challenges in protein stability prediction upon genome variations: towards future applications in precision medicine
Protein stability predictions are becoming essential in medicine to develop novel
immunotherapeutic agents and for drug discovery. Despite the large number of …
immunotherapeutic agents and for drug discovery. Despite the large number of …
DynaMut2: Assessing changes in stability and flexibility upon single and multiple point missense mutations
Predicting the effect of missense variations on protein stability and dynamics is important for
understanding their role in diseases, and the link between protein structure and function …
understanding their role in diseases, and the link between protein structure and function …
Drug-resistance in Mycobacterium tuberculosis: where we stand
A Mabhula, V Singh - Medchemcomm, 2019 - pubs.rsc.org
Tuberculosis (TB), an infectious disease caused by the bacterium Mycobacterium
tuberculosis (Mtb), has burdened vulnerable populations in modern day societies for …
tuberculosis (Mtb), has burdened vulnerable populations in modern day societies for …
Prediction of impacts of mutations on protein structure and interactions: SDM, a statistical approach, and mCSM, using machine learning
AP Pandurangan, TL Blundell - Protein Science, 2020 - Wiley Online Library
Next‐generation sequencing methods have not only allowed an understanding of genome
sequence variation during the evolution of organisms but have also provided invaluable …
sequence variation during the evolution of organisms but have also provided invaluable …
An appraisal of anti-mycobacterial activity with structure-activity relationship of piperazine and its analogues: A review
Piperazine, is privileged six membered nitrogen containing heterocyclic ring also known as
1, 4-Diazacyclohexane. Consequently, piperazine is a versatile medicinally important …
1, 4-Diazacyclohexane. Consequently, piperazine is a versatile medicinally important …
Recent advancements and developments in search of anti-tuberculosis agents: a quinquennial update and future directions
Tuberculosis (TB) has been considered as the highly chronic, contagious and infectious
disorder caused by Mycobacterium tuberculosis (Mtb). Every year more than 10 million …
disorder caused by Mycobacterium tuberculosis (Mtb). Every year more than 10 million …
Current advances in the clinical development of anti-tubercular agents
SR Tetali, E Kunapaeddi, RP Mailavaram, V Singh… - Tuberculosis, 2020 - Elsevier
Tuberculosis (TB) is a communicable airborne infectious disease caused by the
Mycobacterium tuberculosis (MTB) that primarily affects the lungs, and can disseminate to …
Mycobacterium tuberculosis (MTB) that primarily affects the lungs, and can disseminate to …
Tuberculosis: an update on pathophysiology, molecular mechanisms of drug resistance, newer anti-TB drugs, treatment regimens and host-directed therapies
P Borah, PK Deb, KN Venugopala… - Current Topics in …, 2021 - ingentaconnect.com
Human tuberculosis (TB) is primarily caused by Mycobacterium tuberculosis (Mtb) that
inhabits inside and amidst immune cells of the host with adapted physiology to regulate …
inhabits inside and amidst immune cells of the host with adapted physiology to regulate …
[HTML][HTML] Combining structure and genomics to understand antimicrobial resistance
Antimicrobials against bacterial, viral and parasitic pathogens have transformed human and
animal health. Nevertheless, their widespread use (and misuse) has led to the emergence of …
animal health. Nevertheless, their widespread use (and misuse) has led to the emergence of …
An insight into the biological activity and structure-based drug design attributes of sulfonylpiperazine derivatives
The development of new, effective drugs containing nitrogen and sulfur heteroatoms is of
paramount importance in medicinal chemistry. A versatile and rational approach for drug …
paramount importance in medicinal chemistry. A versatile and rational approach for drug …