Glioblastoma multiforme (GBM): An overview of current therapies and mechanisms of resistance

W Wu, JL Klockow, M Zhang, F Lafortune… - Pharmacological …, 2021 - Elsevier
Glioblastoma multiforme (GBM) is a WHO grade IV glioma and the most common malignant,
primary brain tumor with a 5-year survival of 7.2%. Its highly infiltrative nature, genetic …

Blood-brain barrier, blood-brain tumor barrier, and fluorescence-guided neurosurgical oncology: delivering optical labels to brain tumors

E Belykh, KV Shaffer, C Lin, VA Byvaltsev… - Frontiers in …, 2020 - frontiersin.org
Recent advances in maximum safe glioma resection have included the introduction of a host
of visualization techniques to complement intraoperative white-light imaging of tumors …

Advances in glioblastoma therapy: an update on current approaches

RS Angom, NMR Nakka, S Bhattacharya - Brain sciences, 2023 - mdpi.com
Glioblastoma multiforme (GBM) is a primary malignant brain tumor characterized by a high
grade of malignancy and an extremely unfavorable prognosis. The current efficacy of …

Standardized intraoperative 5-ALA photodynamic therapy for newly diagnosed glioblastoma patients: a preliminary analysis of the INDYGO clinical trial

M Vermandel, C Dupont, F Lecomte, HA Leroy… - Journal of neuro …, 2021 - Springer
Purpose Glioblastoma (GBM) is the most aggressive malignant primary brain tumor. The
unfavorable prognosis despite maximal therapy relates to high propensity for recurrence …

Exosomes: promising delivery tools for overcoming blood-brain barrier and glioblastoma therapy

SH Khatami, N Karami, M Taheri-Anganeh… - Molecular …, 2023 - Springer
Gliomas make up virtually 80% of all lethal primary brain tumors and are categorized based
on their cell of origin. Glioblastoma is an astrocytic tumor that has an inferior prognosis …

Recent advances in the therapeutic strategies of glioblastoma multiforme

AF Aldoghachi, AF Aldoghachi, K Breyne, KH Ling… - Neuroscience, 2022 - Elsevier
Glioblastoma multiforme (GBM) is one of the most common, most formidable, and deadliest
malignant types of primary astrocytoma with a poor prognosis. At present, the standard of …

Effect of 5-aminolevulinic acid and sodium fluorescein on the extent of resection in high-grade gliomas and brain metastasis

LC Ahrens, MG Krabbenhøft, RW Hansen, N Mikic… - Cancers, 2022 - mdpi.com
Simple Summary Complete surgical removal of high-grade gliomas (HGG) is known to
increase the overall survival and progression-free survival. Several studies have shown that …

Fluorescein-guided resection of high grade gliomas: a meta-analysis

EJ Smith, K Gohil, CM Thompson, A Naik… - World neurosurgery, 2021 - Elsevier
Background High-grade gliomas (HGGs) have a poor prognosis despite current standard of
care of surgery, chemotherapy, and radiation therapy. Achieving gross total resection (GTR) …

Surgical management of Glioma Grade 4: technical update from the neuro-oncology section of the Italian Society of Neurosurgery (SINch®): a systematic review

T Ius, G Sabatino, PP Panciani, MM Fontanella… - Journal of neuro …, 2023 - Springer
Purpose The extent of resection (EOR) is an independent prognostic factor for overall
survival (OS) in adult patients with Glioma Grade 4 (GG4). The aim of the neuro-oncology …

[HTML][HTML] Nanoparticle-based drug delivery across the blood-brain barrier for treating malignant brain glioma

V Kurawattimath, B Wilson, KM Geetha - OpenNano, 2023 - Elsevier
In spite of substantial progress made in the standard treatment and ancillary therapies that
include concurrent chemotherapy, radiotherapy, and surgery, malignant brain tumors …