Two genes are synthetic lethal if mutation of either alone is compatible with viability but
mutation of both leads to death. So, targeting a gene that is synthetic lethal to a cancer …

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The Yeasts: A Taxonomic Study is a three-volume book that covers the taxonomic aspect of
yeasts. The main goal of this book is to provide important information about the identification …

Discovering target and off-target effects of specific compounds is critical to drug discovery
and development. We generated a compendium of" chemical-genetic interaction" profiles by …

Candida albicans is a prevalent fungal pathogen amongst the immunocompromised
population, causing both superficial and life-threatening infections. Since C. albicans is …

In the past, studies using the yeast Saccharomyces cerevisiae enabled major breakthroughs
in the understanding of basic cellular and molecular processes. Today, the use of yeast is …

Genomic deletion of tumor suppressor genes (TSGs) is a rite of passage for virtually all
human cancers. The synthetic lethal paradigm has provided a framework for the …

Mutants with a defective non-homologous-end-joining (NHEJ) pathway have boosted
functional genomics in filamentous fungi as they are very efficient recipient strains for gene …

Starting with the discovery of penicillin, the pharmaceutical industry has relied extensively
on natural products (NPs) as an unparalleled source of bioactive small molecules suitable …

There is no doubt that the existing arsenal of antimicrobial agents we have in hand for the
treatment of infectious diseases is insufficient to protect us over the long term. 1-3 The …