Toxin-antitoxin systems in bacterial growth arrest and persistence

R Page, W Peti - Nature chemical biology, 2016 - nature.com
Bacterial persister cells constitute a subpopulation of genetically identical, metabolically
slow-growing cells that are highly tolerant of antibiotics and other environmental stresses …

Toxin–antitoxin systems: biology, identification, and application

SJ Unterholzner, B Poppenberger… - Mobile genetic …, 2013 - Taylor & Francis
Toxin–antitoxin (TA) systems are small genetic elements composed of a toxin gene and its
cognate antitoxin. The toxins of all known TA systems are proteins while the antitoxins are …

An Escherichia coli chromosomal" addiction module" regulated by guanosine [corrected] 3', 5'-bispyrophosphate: a model for programmed bacterial cell death.

E Aizenman, H Engelberg-Kulka… - Proceedings of the …, 1996 - National Acad Sciences
" Addiction modules" consist of two genes. In most of them the product of one is long lived
and toxic while the product of the second is short lived and antagonizes the toxic effect; so …

Bacterial antisense RNAs: how many are there, and what are they doing?

MK Thomason, G Storz - Annual review of genetics, 2010 - annualreviews.org
Antisense RNAs encoded on the DNA strand opposite another gene have the potential to
form extensive base-pairing interactions with the corresponding sense RNA. Unlike other …

Analysis of the sequence and gene products of the transfer region of the F sex factor

LS Frost, K Ippen-Ihler, RA Skurray - Microbiological reviews, 1994 - Am Soc Microbiol
Bacterial conjugation results in the transfer of DNA of either plasmid or chromosomal origin
between microorganisms. Transfer begins at a defined point in the DNA sequence, usually …

To be or not to be: regulation of restriction–modification systems and other toxin–antitoxin systems

I Mruk, I Kobayashi - Nucleic acids research, 2014 - academic.oup.com
One of the simplest classes of genes involved in programmed death is that containing the
toxin–antitoxin (TA) systems of prokaryotes. These systems are composed of an intracellular …

Toxin–Antitoxin systems: their role in persistence, biofilm formation, and pathogenicity

Y Wen, E Behiels, B Devreese - Pathogens and disease, 2014 - academic.oup.com
One of the most pertinent recent outcomes of molecular microbiology efforts to understand
bacterial behavior is the discovery of a wide range of toxin–antitoxin (TA) systems that are …

Oligoribonucleotides and ribonucleases for cleaving RNA

ST Crooke - US Patent 6,107,094, 2000 - Google Patents
Mackiewicz & Norris LLP 57 ABSTRACT Oligomeric compounds including
oligoribonucleotides and oligoribonucleosides are provided that have Subsequences of 2' …

[HTML][HTML] Toxin-antitoxin systems as multilevel interaction systems

N Goeders, L Van Melderen - Toxins, 2014 - mdpi.com
Toxin-antitoxin (TA) systems are small genetic modules usually composed of a toxin and an
antitoxin counteracting the activity of the toxic protein. These systems are widely spread in …

Toxins-antitoxins: diversity, evolution and function

F Hayes, L Van Melderen - Critical reviews in biochemistry and …, 2011 - Taylor & Francis
Genes for toxin-antitoxin (TA) complexes are widespread in prokaryote genomes, and
species frequently possess tens of plasmid and chromosomal TA loci. The complexes are …