Navigation through the bulk tumour, entry into the blood vasculature, survival in the
circulation, exit at distant sites and resumption of proliferation are all steps necessary for …

The ability to study cellular physiology using photosensitive, genetically encoded molecules
has profoundly transformed neuroscience. The modern optogenetic toolbox includes …

Phytochrome photoreceptors absorb far-red and near-infrared (NIR) light and regulate light
responses in plants, fungi, and bacteria. Their multidomain structure and autocatalytic …

Many aspects of plant photoperception are mediated by the phytochrome (Phy) family of
bilin-containing photoreceptors that reversibly interconvert between inactive Pr and active …

Optogenetic tools use colored light to rapidly control gene expression in space and time. We
designed a genetically encoded system that gives Escherichia coli the ability to distinguish …

Animal development is characterized by signaling events that occur at precise locations and
times within the embryo, but determining when and where such precision is needed for …

Synthetic biology concerns the engineering of man‐made living biomachines from
standardized components that can perform predefined functions in a (self‐) controlled …

Cells are bombarded by extrinsic signals that dynamically change in time and space. Such
dynamic variations can exert profound effects on behaviors, including cellular signaling …

Multifunctional optogenetic systems are in high demand for use in basic and biomedical
research. Near-infrared-light-inducible binding of bacterial phytochrome BphP1 to its natural …

The development of multicellular organisms is controlled by highly dynamic molecular and
cellular processes organized in spatially restricted patterns. Recent advances in …