Metabolomics as a valid analytical technique in environmental exposure research: application and progress

S Wei, Y Wei, Y Gong, Y Chen, J Cui, L Li, H Yan, Y Yu… - Metabolomics, 2022 - Springer
Background In recent years, studies have shown that exposure to environmental pollutants
(eg, radiation, heavy metal substances, air pollutants, organic pollutants) is a leading cause …

Application of radiation omics in the development of adverse outcome pathway networks: an example of radiation-induced cardiovascular disease

O Azimzadeh, S Moertl, R Ramadan… - … Journal of Radiation …, 2022 - Taylor & Francis
Background Epidemiological studies have indicated that exposure of the heart to doses of
ionizing radiation as low as 0.5 Gy increases the risk of cardiac morbidity and mortality with …

Two-miRNA–based finger-stick assay for estimation of absorbed ionizing radiation dose

M Yadav, S Bhayana, J Liu, L Lu, J Huang… - Science translational …, 2020 - science.org
Nuclear radiation and radioactive fallouts resulting from a nuclear weapon detonation or
reactor accidents could result in injuries affecting multiple sensitive organs, defined as acute …

[HTML][HTML] Radiation exposure induces cross-species temporal metabolic changes that are mitigated in mice by amifostine

A Crook, A De Lima Leite, T Payne, F Bhinderwala… - Scientific reports, 2021 - nature.com
Exposure to acute, damaging radiation may occur through a variety of events from cancer
therapy and industrial accidents to terrorist attacks and military actions. Our understanding of …

[HTML][HTML] The NIAID/RNCP biodosimetry program: An overview

MM Satyamitra, DR Cassatt, O Molinar-Inglis… - … and Genome Research, 2023 - karger.com
Established in 2004, the Radiation and Nuclear Countermeasures Program (RNCP), within
the National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health …

Liquid chromatography–mass spectrometry-based metabolomics of nonhuman primates after 4 Gy total body radiation exposure: global effects and targeted panels

EL Pannkuk, EC Laiakis, K Gill, SK Jain… - Journal of proteome …, 2019 - ACS Publications
Rapid assessment of radiation signatures in noninvasive biofluids may aid in assigning
proper medical treatments for acute radiation syndrome (ARS) and delegating limited …

[HTML][HTML] Effects of low dose space radiation exposures on the splenic metabolome

EC Laiakis, I Shuryak, A Deziel, YW Wang… - International journal of …, 2021 - mdpi.com
Future space missions will include a return to the Moon and long duration deep space
roundtrip missions to Mars. Leaving the protection that Low Earth Orbit provides will …

[HTML][HTML] A systematic review of metabolomic and lipidomic candidates for biomarkers in radiation injury

E Vicente, Z Vujaskovic, IL Jackson - Metabolites, 2020 - mdpi.com
A large-scale nuclear event has the ability to inflict mass casualties requiring point-of-care
and laboratory-based diagnostic and prognostic biomarkers to inform victim triage and …

Lipidomics and environmental toxicology: Recent trends

JJ Aristizabal-Henao, A Ahmadireskety… - Current Opinion in …, 2020 - Elsevier
The versatility of lipidomic applications has been increasingly recognized in environmental
toxicology in recent years. The unmatched diversity and ubiquitous nature of lipids makes …

[HTML][HTML] Exploring radiation response in two head and neck squamous carcinoma cell lines through metabolic profiling

E Lindell Jonsson, I Erngren, M Engskog… - Frontiers in …, 2019 - frontiersin.org
Head and neck squamous cell carcinoma (HNSCC) is the sixth most common form of cancer
worldwide. Radiotherapy, with or without surgery, represents the major approach to curative …