ACE2: Evidence of role as entry receptor for SARS-CoV-2 and implications in comorbidities
N Zamorano Cuervo, N Grandvaux - elife, 2020 - elifesciences.org
Pandemic severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes
coronavirus 19 disease (COVID-19) which presents a large spectrum of manifestations with …
coronavirus 19 disease (COVID-19) which presents a large spectrum of manifestations with …
GRP78: A cell's response to stress
Abstract Background Glucose-Regulated Protein 78 (GRP78) is a chaperone heat shock
protein that has been intensely studied in the last two decades. GRP78 is the master of the …
protein that has been intensely studied in the last two decades. GRP78 is the master of the …
COVID-19 spike-host cell receptor GRP78 binding site prediction
Objectives Understanding the novel coronavirus (COVID-19) mode of host cell recognition
may help to fight the disease and save lives. The spike protein of coronaviruses is the main …
may help to fight the disease and save lives. The spike protein of coronaviruses is the main …
Natural products may interfere with SARS-CoV-2 attachment to the host cell
AA Elfiky - Journal of Biomolecular Structure and Dynamics, 2021 - Taylor & Francis
SARS-CoV-2 has been emerged in December 2019 in China, causing deadly (5% mortality)
pandemic pneumonia, termed COVID-19. More than one host-cell receptor is reported to be …
pandemic pneumonia, termed COVID-19. More than one host-cell receptor is reported to be …
Functionalizing nanoparticles with biological molecules: developing chemistries that facilitate nanotechnology
KE Sapsford, WR Algar, L Berti, KB Gemmill… - Chemical …, 2013 - ACS Publications
Bionanotechnology has now become firmly established in its own right as one of the
principle and focused subdisciplines within nanotechnology.(1-10) Bionanotechnology can …
principle and focused subdisciplines within nanotechnology.(1-10) Bionanotechnology can …
Glucose-regulated proteins in cancer: molecular mechanisms and therapeutic potential
AS Lee - Nature Reviews Cancer, 2014 - nature.com
The glucose-regulated proteins (GRPs) are stress-inducible chaperones that mostly reside
in the endoplasmic reticulum or the mitochondria. Recent advances show that the GRPs …
in the endoplasmic reticulum or the mitochondria. Recent advances show that the GRPs …
CAR T cells redirected to cell surface GRP78 display robust anti-acute myeloid leukemia activity and do not target hematopoietic progenitor cells
Developing CAR T cells for acute myeloid leukemia (AML) has been hampered by a paucity
of targets that are expressed on AML blasts and not on hematopoietic progenitor cells …
of targets that are expressed on AML blasts and not on hematopoietic progenitor cells …
Design of virus-based nanomaterials for medicine, biotechnology, and energy
AM Wen, NF Steinmetz - Chemical Society Reviews, 2016 - pubs.rsc.org
This review provides an overview of recent developments in “chemical virology.” Viruses, as
materials, provide unique nanoscale scaffolds that have relevance in chemical biology and …
materials, provide unique nanoscale scaffolds that have relevance in chemical biology and …
The critical roles of endoplasmic reticulum chaperones and unfolded protein response in tumorigenesis and anticancer therapies
B Luo, AS Lee - Oncogene, 2013 - nature.com
Cancer progression is characterized by rapidly proliferating cancer cells that are in need of
increased protein synthesis. Therefore, enhanced endoplasmic reticulum (ER) activity is …
increased protein synthesis. Therefore, enhanced endoplasmic reticulum (ER) activity is …
Beyond the endoplasmic reticulum: atypical GRP78 in cell viability, signalling and therapeutic targeting
GRP78 (glucose-regulated protein of 78 kDa) is traditionally regarded as a major ER
(endoplasmic reticulum) chaperone facilitating protein folding and assembly, protein quality …
(endoplasmic reticulum) chaperone facilitating protein folding and assembly, protein quality …