The AIDS pandemic continues to present us with unique scientific and public health
challenges. Although the development of effective antiretroviral therapy has been a major …

Thorough research on HIV is progressively enabling us to understand the intricate
mechanisms that link HIV‐1 infection to the onset of immunodeficiency. The infection and …

▪ Abstract Human immunodeficiency virus-1 (HIV-1) is usually transmitted through sexual
contact and in the very early stages of infection establishes a persistent infection in …

Much effort has been devoted to the design of vaccines that induce adaptive cellular
immunity, in particular CD8+ T cells, which have a central role in the host response to viral …

Treatment of HIV‐infected patients with highly active antiretroviral therapy (HAART) usually
results in diminished viral replication, increasing CD4+ cell counts, a reversal of most …

The mechanisms of CD4+ T-cell count decline, the hallmark of HIV disease progression, and
its relationship to elevated levels of immune activation are not fully understood. Massive …

Critical to the development of an effective HIV/AIDS model is the production of an animal
model that reproduces long-lasting active replication of HIV-1 followed by elicitation of virus …

A unique definition of INR is currently unavailable. Over the years, INRs have generally
been described as subjects who did not reach pre-defined CD4+ lymphocyte counts (ie 200 …

Although combination antiretroviral therapy can dramatically reduce the circulating viral load
in those infected with HIV, replication-competent virus persists. To eliminate the need for …

T cells play a central role in the development of immune responses. Patients lacking T cells
because of genetic defects such as DiGeorge or Nezelof syndromes and patients infected …