A fundamental task in various disciplines of science, including biology, is to find underlying
causal relations and make use of them. Causal relations can be seen if interventions are …

Some of the biological knowledge obtained from fundamental research will be implemented
in applied plant breeding. To bridge basic research and breeding practice, machine learning …

Networks are vital tools for understanding and modeling interactions in complex systems in
science and engineering, and direct and indirect interactions are pervasive in all types of …

Transcriptional regulation is a fundamental molecular mechanism involved in almost every
aspect of life, from homeostasis to development, from metabolism to behavior, from reaction …

Expression reprogramming directed by transcription factors is a primary gene regulation
underlying most aspects of the biology of any organism. Our views of how gene regulation is …

Deciphering gene regulatory networks (GRNs) is both a promise and challenge of systems
biology. The promise lies in identifying key transcription factors (TFs) that enable an …

Highlights•GRNs represent causal relationships among regulators and their downstream
genes.•Biological hypothesis drives data collection and the subsequent inferred …

Precision medicine is the personalization of medicine to suit a specific group of people or
even an individual patient, based on genetic or molecular profiling. This can be done using …

Plants intricately deploy defense systems to counter diverse biotic and abiotic stresses.
Omics technologies, spanning genomics, transcriptomics, proteomics, and metabolomics …

Gene regulatory networks (GRNs) represent the interactions between transcription factors
(TF) and their target genes. Plant GRNs control transcriptional programs involved in growth …