Erectile dysfunction is a common clinical entity that affects mainly men older than 40 years.
In addition to the classical causes of erectile dysfunction, such as diabetes mellitus and …

To date, studies suggest that biological signaling by nitric oxide (NO) is primarily mediated
by cGMP, which is synthesized by NO-activated guanylyl cyclases and broken down by …

Background: The term “chemsex” was coined to indicate the voluntary intake of psychoactive
and non psychoactive drugs in the context of recreational settings to facilitate and/or to …

Erection is basically a spinal reflex that can be initiated by recruitment of penile afferents,
both autonomic and somatic, and supraspinal influences from visual, olfactory, and …

PDE type 5 inhibitors (PDE5Is), such as sildenafil, tadalafil and vardenafil, are a class of
drugs used to prolong the physiological effects of NO/cGMP signalling in tissues through the …

Ethnopharmacological relevance The prevalence and distress caused by erectile
dysfunction (ED) to both male and female partners are increasing at a steady rate. ED has …

Introduction Erectile dysfunction (ED) is a very common multidimensional disorder affecting
men worldwide. Physical illness, reaction to life stresses, or an unhappy couple relationship …

Selective phosphodiesterase 5 inhibitors, including sildenafil, tadalafil and vardenafil, are
widely-used in the treatment of erectile dysfunction and pulmonary arterial hypertension …

Introduction: Phosphodiesterase type 5 inhibitors (PDE5Is) are the leading drugs for the
treatment of erectile dysfunction (ED), being recommended as a first line treatment by both …

Liver fibrosis is a health concern that leads to organ failure mediated via production of
inflammatory cytokines and fibrotic biomarkers. This study aimed to explore the protective …